3-(2,4-Dimethoxybenzoyl)acrylic Acid | 78149-70-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(2,4-Dimethoxybenzoyl)acrylic Acid
• 英文别名: 4-oxo-4-(2.4-dimethoxy-phenyl)-trans-crotonic acid；4-Oxo-4-(2.4-dimethoxy-phenyl)-trans-crotonsaeure；(E)-4-(2,4-Dimethoxyphenyl)-4-oxo-2-butenoic acid；(E)-4-(2,4-dimethoxyphenyl)-4-oxobut-2-enoic acid
• CAS: 78149-70-9
• 化学式: C₁₂H₁₂O₅
• 分子量: 236.224
• InChiKey: CGJMPMCLHKGKJV-AATRIKPKSA-N

物化性质

• 熔点：
  189-190 °C (decomp)
• 沸点：
  446.3±45.0 °C(Predicted)
• 密度：
  1.241±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-(2,4-Dimethoxybenzoyl)acrylic Acid 在 三氯化铝 作用下， 生成 2,4-bis-(2,4-dimethoxy-phenyl)-4-oxo-butyric acid methyl ester
  参考文献：
  名称：

  Optical tweezers for confocal microscopy

  摘要：

  In confocal laser scanning microscopes (CLSMs), lasers can be used for image formation as well as tools for the manipulation of microscopic objects. In the latter case, in addition to the imaging lasers, the light of an extra laser has to be focused into the object plane of the CLSM, for example as optical tweezers. Imaging as well as trapping by optical tweezers can be done using the same objective lens. In this case, z-sectioning for 3D imaging shifts the optical tweezers with the focal plane of the objective along the optical axis, so that a trapped object remains positioned in the focal plane. Consequently, 3D imaging of trapped objects is impossible without further measures. We present an experimental set-up keeping the axial trapping position of the optical tweezers at its intended position whilst the focal plane can be axially shifted over a distance of about 15 mum. It is based on fast-moving correctional optics synchronized with the objective movement. First examples of application are the 3D imaging of chloroplasts of Elodea densa (Canadian waterweed) in a vigorous cytoplasmic streaming and the displacement of zymogen granules in pancreatic cancer cells (AR42 J).

  DOI：

  10.1007/s003400000454
• 作为产物：
  描述：

  4-(2,5-dimethoxyphenyl)-4-oxo-2-hydroxy-butanoic acid 在 盐酸 作用下， 以 溶剂黄146 为溶剂， 反应 20.0h， 以58%的产率得到3-(2,4-Dimethoxybenzoyl)acrylic Acid
  参考文献：
  名称：

  Gastric anti-secretory, anti-ulcer and cytoprotective properties of substituted (E)-4-phenyl- and heteroaryl-4-oxo-2-butenoic acids

  摘要：

  DOI：

  10.1016/0223-5234(88)90166-3

文献信息

• Papa et al., Journal of the American Chemical Society, 1948, vol. 70, p. 3356,3357
  作者：Papa et al.

  DOI：——

  日期：——
• Preparation and Diels-Alder reaction of some benzoylacrylic acids
  作者：Robert C. Bugle、Desmond M. S. Wheeler、Margaret M. Wheeler、James R. Hohman

  DOI：10.1021/jo00332a033

  日期：1981.9
• BUGLE, R. C.;WHEELER, D. M. S.;WHEELER, M. M.;HOHMAN, J. R., J. ORG. CHEM., 1981, 46, N 19, 3915-3917
  作者：BUGLE, R. C.、WHEELER, D. M. S.、WHEELER, M. M.、HOHMAN, J. R.

  DOI：——

  日期：——
• Optical tweezers for confocal microscopy
  作者：A. Hoffmann、G. Meyer zu Hörste、G. Pilarczyk、S. Monajembashi、V. Uhl、K.O. Greulich

  DOI：10.1007/s003400000454

  日期：2000.11

  In confocal laser scanning microscopes (CLSMs), lasers can be used for image formation as well as tools for the manipulation of microscopic objects. In the latter case, in addition to the imaging lasers, the light of an extra laser has to be focused into the object plane of the CLSM, for example as optical tweezers. Imaging as well as trapping by optical tweezers can be done using the same objective lens. In this case, z-sectioning for 3D imaging shifts the optical tweezers with the focal plane of the objective along the optical axis, so that a trapped object remains positioned in the focal plane. Consequently, 3D imaging of trapped objects is impossible without further measures. We present an experimental set-up keeping the axial trapping position of the optical tweezers at its intended position whilst the focal plane can be axially shifted over a distance of about 15 mum. It is based on fast-moving correctional optics synchronized with the objective movement. First examples of application are the 3D imaging of chloroplasts of Elodea densa (Canadian waterweed) in a vigorous cytoplasmic streaming and the displacement of zymogen granules in pancreatic cancer cells (AR42 J).
• Gastric anti-secretory, anti-ulcer and cytoprotective properties of substituted (E)-4-phenyl- and heteroaryl-4-oxo-2-butenoic acids
  作者：Mario Bianchi、Alina Butti、Yani Christidis、Jacques Perronnet、Fernando Barzaghi、Raffaele Cesana、Alberto Nencioni

  DOI：10.1016/0223-5234(88)90166-3

  日期：1988.1