1-O-palmitoyl-2-[(9z,12z)-octadenoyl]-glycerol | 51621-26-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1-O-palmitoyl-2-[(9z,12z)-octadenoyl]-glycerol
• 英文别名: 1-Palmitoyl-2-linoleoyl-sn-glycerol；[(2S)-1-hexadecanoyloxy-3-hydroxypropan-2-yl] (9Z,12Z)-octadeca-9,12-dienoate
• CAS: 51621-26-2
• 化学式: C₃₇H₆₈O₅
• 分子量: 592.944
• InChiKey: SVXWJFFKLMLOHO-YAIZGCQRSA-N

物化性质

• 物理描述：
  Solid
• 碰撞截面：
  257.06 Ų [M+NH4]+ [CCS Type: TIMS, Method: single field calibrated]

计算性质

• 辛醇/水分配系数(LogP)：
  13.5
• 重原子数：
  42
• 可旋转键数：
  34
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-O-palmitoyl-2-[(9z,12z)-octadenoyl]-glycerol 、 1-anthroylnitrile 、 4-二甲氨基吡啶 生成 [3-hexadecanoyloxy-2-[(9Z,12Z)-octadeca-9,12-dienoyl]oxypropyl] anthracene-1-carboxylate
  参考文献：
  名称：

  RAMESHA, CHAKKODABYLU S.;PICKETT, WALTER C.;KRISHNA, MURTHY D. V., J. CHROMATOGR. BIOMED. APPL., 491,(1989) N, C. 37-48

  摘要：

  DOI：
• 作为产物：
  描述：

  1-O-palmitoyl-2-[(9z,12z)-octadenoyl]-3-benzylglycerol 在 三氯化硼 作用下， 以 二氯甲烷 为溶剂， 以88%的产率得到1-O-palmitoyl-2-[(9z,12z)-octadenoyl]-glycerol
  参考文献：
  名称：

  Synthesis of a Small Library of Mixed-Acid Phospholipids from D-Mannitol as a Homochiral Starting Material.

  摘要：

  描述了一种使用新保护策略合成一系列含有多不饱和脂肪酸的混酸磷脂。具体而言，分别用BCl3和354 nm的光去除的保护基团是苄基和甲基α-(2, 4-二硝基苯基)乙酸。

  DOI：

  10.1248/cpb.47.1659

文献信息

• NOVEL PHOSPHATIDYLALKANOLS AND COMPOSITIONS THEREOF
  申请人：PETHMARK AB

  公开号：US20160052946A1

  公开（公告）日：2016-02-25

  The present invention discloses a composition comprising a compound of formula I and a deuterated solvent. The deuterated solvent is miscible with water in any proportion at a temperature of 20 to 25° C. and comprises less than 5% residual 1 H-isotopes. The concentration of the compound of formula I may advantageously be determined by 1 H-QNMR. Methods of production of the composition and salts of compounds of formula I, as well as related analogs and novel reagents and intermediates for the production thereof, are also described.

  本发明揭示了一种包含式I化合物和氘化溶剂的组合物。氘化溶剂在20至25°C温度下与水可任意比例混合，并且含有少于5%的残留1H同位素。化合物式I的浓度可优选通过1H-QNMR确定。还描述了该组合物的生产方法、式I化合物的盐、以及相关类似物和新型试剂和中间体的生产方法。
• Oxidized lipid detection
  申请人：KRATOS ANALYTICAL LIMITED

  公开号：US10948502B2

  公开（公告）日：2021-03-16

  The present invention is concerned with a method of extracting oxidized lipids from a lipid solution, the method comprising (a) a derivatisation step, comprising contacting a derivatisation agent with the lipid solution such that aldehydic oxidized lipids and/or α,β-unsaturated oxidised lipids, if present in the lipid solution, are derivatised to include an anionic group, and (b) an oxidised lipid capture step, in which nanoparticles are contacted with the lipid solution, wherein the nanoparticles capture anionic-group containing oxidised lipids. The invention also includes a method of extracting aldehydic oxidized phospholipids from a lipid solution, the method comprising (a) a derivatisation step, comprising introduction of a anionic group to aldehydic oxidized lipids and/or α,β-unsaturated oxidised lipids in the lipid solution, and (b) an oxidised lipid capture step, in which nanoparticles are contacted with the lipid solution, wherein the nanoparticles bind anionic-group containing oxidised lipids.

  本发明涉及一种从脂质溶液中提取氧化脂质的方法，该方法包括(a)衍生化步骤，包括将衍生化剂与脂质溶液接触，使脂质溶液中存在的醛氧化脂质和/或α、(b) 氧化脂质捕获步骤，其中纳米颗粒与脂质溶液接触，纳米颗粒捕获含有阴离子基团的氧化脂质。本发明还包括一种从脂溶液中提取醛氧化磷脂的方法，该方法包括：(a) 衍生化步骤，包括向脂溶液中的醛氧化脂和（或）α，β-不饱和氧化脂中引入阴离子基团；(b) 氧化脂捕获步骤，其中纳米颗粒与脂溶液接触，纳米颗粒结合含有阴离子基团的氧化脂。
• RAMESHA, CHAKKODABYLU S.;PICKETT, WALTER C.;KRISHNA, MURTHY D. V., J. CHROMATOGR. BIOMED. APPL., 491,(1989) N, C. 37-48
  作者：RAMESHA, CHAKKODABYLU S.、PICKETT, WALTER C.、KRISHNA, MURTHY D. V.

  DOI：——

  日期：——
• Characterization of the Human LPIN1-encoded Phosphatidate Phosphatase Isoforms
  作者：Gil-Soo Han、George M. Carman

  DOI：10.1074/jbc.m110.117747

  日期：2010.5

  The human LPIN1 gene encodes the protein lipin 1, which possesses phosphatidate (PA) phosphatase (3-sn-phosphatidate phosphohydrolase; EC 3.1.3.4) activity (Han, G.-S., Wu, W.-I., and Carman, G. M. (2006) J. Biol. Chem. 281, 9210-9218). In this work, we characterized human lipin 1 alpha, beta, and gamma isoforms that were expressed in Escherichia coli and purified to near homogeneity. PA phosphatase activities of the alpha, beta, and gamma isoforms were dependent on Mg2+ or Mn2+ ions at pH 7.5 at 37 degrees C. The activities were inhibited by concentrations of Mg2+ and Mn2+ above their optimums and by Ca2+, Zn2+, N-ethylmaleimide, propranolol, and the sphingoid bases sphingosine and sphinganine. The activities were thermally labile at temperatures above 40 degrees C. The alpha, beta, and gamma activities followed saturation kinetics with respect to the molar concentration of PA (K-m values of 0.35, 0.24, and 0.11 mM, respectively) but followed positive cooperative (Hill number similar to 2) kinetics with respect to the surface concentration of PA (K-m values of 4.2, 4.5, and 4.3 mol %, respectively) in Triton X-100/PA-mixed micelles. The turnover numbers (k(cat)) for the alpha, beta, and gamma isoforms were 68.8 +/- 3.5, 42.8 +/- 2.5, and 5.7 +/- 0.2 s(-1), respectively, whereas their energy of activation values were 14.2, 15.5, and 18.5 kcal/mol, respectively. The isoform activities were dependent on PA as a substrate and required at least one unsaturated fatty acyl moiety for maximum activity.
• Process for the partial hydrogenation of fatty acid esters
  申请人：Cognis IP Management GmbH

  公开号：EP1918358B1

  公开（公告）日：2012-08-01