(4-Methyl-pyridin-2-yl)-((S)-1-phenyl-ethyl)-carbamic acid tert-butyl ester | 552317-80-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (4-Methyl-pyridin-2-yl)-((S)-1-phenyl-ethyl)-carbamic acid tert-butyl ester
• 英文别名: tert-butyl N-(4-methylpyridin-2-yl)-N-[(1S)-1-phenylethyl]carbamate
• CAS: 552317-80-3
• 化学式: C₁₉H₂₄N₂O₂
• 分子量: 312.412
• InChiKey: VBHYWZPGFXNMEM-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (4-Methyl-pyridin-2-yl)-((S)-1-phenyl-ethyl)-carbamic acid tert-butyl ester 在 盐酸 、 氢溴酸 、 溴 、 sodium hexamethyldisilazane 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Imidazopyrimidines, potent inhibitors of p38 MAP kinase

  摘要：

  The MAP kinase p38 is implicated in the release of the pro-inflammatory cytokines TNF-alpha and IL-1beta. Inhibition of cytokine release may be a useful treatment for inflammatory conditions such as rheumatoid arthritis and Crohn's disease. A novel series of imidazopyrimidines have been discovered that potently inhibit p38 and suppress the production of TNF-alpha in vivo. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)01020-x
• 作为产物：
  描述：

  2-溴-4-甲基吡啶 在 tris(dibenzylideneacetone)dipalladium (0) 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 、 sodium t-butanolate 作用下， 以 叔丁醇 为溶剂， 生成 (4-Methyl-pyridin-2-yl)-((S)-1-phenyl-ethyl)-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Imidazopyrimidines, potent inhibitors of p38 MAP kinase

  摘要：

  The MAP kinase p38 is implicated in the release of the pro-inflammatory cytokines TNF-alpha and IL-1beta. Inhibition of cytokine release may be a useful treatment for inflammatory conditions such as rheumatoid arthritis and Crohn's disease. A novel series of imidazopyrimidines have been discovered that potently inhibit p38 and suppress the production of TNF-alpha in vivo. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)01020-x

文献信息

• Imidazopyrimidines, potent inhibitors of p38 MAP kinase
  作者：Kenneth C Rupert、James R Henry、John H Dodd、Scott A Wadsworth、Druie E Cavender、Gilbert C Olini、Bohumila Fahmy、John J Siekierka

  DOI：10.1016/s0960-894x(02)01020-x

  日期：2003.2

  The MAP kinase p38 is implicated in the release of the pro-inflammatory cytokines TNF-alpha and IL-1beta. Inhibition of cytokine release may be a useful treatment for inflammatory conditions such as rheumatoid arthritis and Crohn's disease. A novel series of imidazopyrimidines have been discovered that potently inhibit p38 and suppress the production of TNF-alpha in vivo. (C) 2002 Elsevier Science Ltd. All rights reserved.