3-benzyl-3-((dimethylamino)methyl)-1-methylindolin-2-one | 1269048-69-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-benzyl-3-((dimethylamino)methyl)-1-methylindolin-2-one
• 英文别名: 3-Benzyl-3-[(dimethylamino)methyl]-1-methylindol-2-one；3-benzyl-3-[(dimethylamino)methyl]-1-methylindol-2-one
• CAS: 1269048-69-2
• 化学式: C₁₉H₂₂N₂O
• 分子量: 294.396
• InChiKey: TXEFMBCBTSPCEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 3-苄基-1,3-二氢-1-甲基-2H-吲哚-2-酮 、 二甲胺 在 sodium dodecyl-sulfate 作用下， 以 水 为溶剂， 反应 3.0h， 以74%的产率得到3-benzyl-3-((dimethylamino)methyl)-1-methylindolin-2-one
  参考文献：
  名称：

  A simple and eco-friendly method for the aminomethylation of 3-substituted oxindoles via three-component Mannich reaction in aqueous media

  摘要：

  A simple and eco-friendly method for the aminomethylation of various 3-substituted oxindoles via three-component Mannich reaction in aqueous media has been established. A variety of oxindoles containing a quaternary carbon center, which comprises an aminomethyl group were obtained smoothly in good yields (up to 93%) with this method. Particularly valuable features, such as employing cheap and readily available formalin as a useful aminomethylation Cl unit and using water as a reaction medium, are embodied in this method. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.12.060

文献信息

• A simple and eco-friendly method for the aminomethylation of 3-substituted oxindoles via three-component Mannich reaction in aqueous media
  作者：Xiong-Li Liu、Xiao-Mei Zhang、Wei-Cheng Yuan

  DOI：10.1016/j.tetlet.2010.12.060

  日期：2011.2

  A simple and eco-friendly method for the aminomethylation of various 3-substituted oxindoles via three-component Mannich reaction in aqueous media has been established. A variety of oxindoles containing a quaternary carbon center, which comprises an aminomethyl group were obtained smoothly in good yields (up to 93%) with this method. Particularly valuable features, such as employing cheap and readily available formalin as a useful aminomethylation Cl unit and using water as a reaction medium, are embodied in this method. (C) 2010 Elsevier Ltd. All rights reserved.