3,7-二甲基辛烷-1-硫醇 | 138077-76-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醇
• 中文名称: 3,7-二甲基辛烷-1-硫醇
• 英文名称: dihydrothiocitronellol
• 英文别名: 3,7-Dimethyloctane-1-thiol
• CAS: 138077-76-6
• 化学式: C₁₀H₂₂S
• 分子量: 174.351
• InChiKey: RQWWXOUTWRSURG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3,7-二甲基辛烷-1-硫醇 在 三氟化硼乙醚 、 三甲胺 作用下， 以 甲醇 、 氯仿 为溶剂， 反应 24.25h， 生成 (R,S)-3,7-dimethyloctyl 1-thio-β-L-arabinopyranoside
  参考文献：
  名称：

  Synthesis, purification and liquid-crystalline behaviour of several alkyl 1-thio-d-glycopyranosides

  摘要：

  This paper describes the synthesis, purification, and liquid-crystalline behaviour of a series of alkyl 1-thioglycopyranosides. The synthesis of these derivatives was carried out via a Lewis acid mediated coupling of the fully acetylated monosaccharide with an alkanethiol. The choice of the Lewis acid depends on the configuration of AcO-2, The carbohydrate-derived surfactants exhibit thermotropic liquid-crystalline behaviour. The alkyl 1-thioglycopyranosides form the expected smectic A phases upon heating. The clearing temperatures vary with alkyl chain length which is in accordance with the accepted model for the S-A phase of amphiphilic carbohydrate mesogens. For the alkyl 1-thiotalopyranosides, the clearing points are much lower than expected, presumably due to the formation of an intramolecular hydrogen bond in the talose moiety. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0008-6215(97)00185-7
• 作为产物：
  描述：

  3,7-dimethyloctyl 4-methylbenzenesulfonate 在 lithium aluminium tetrahydride 作用下， 以 乙醚 、 N,N-二甲基甲酰胺 为溶剂， 生成 3,7-二甲基辛烷-1-硫醇
  参考文献：
  名称：

  通过改变关键食品气味1- p-甲基蒽8-硫醇的结构基序合成的单萜类硫醇的结构-气味活性研究

  摘要：

  1- p-甲基-Nenthene-8-硫醇（1）几十年前被发现是柚子汁中的主要气味物质，它对水果的整体气味有贡献，在空气中的气味阈值极低，仅为0.000034 ng / L。该值是有史以来针对食品气味剂报告的最低气味阈值之一。为了检查结构1的修饰是否会导致气味阈值和气味质量的变化，使用了34个含巯基的对薄荷烷和1- p合成了薄荷烯衍生物以及几种芳族和开链巯基单萜。文献中首次报道了其中的18种，并提供了它们的气味阈值和气味质量以及分析数据。感官数据与1的感官数据比较表明，双键的氢化导致气味阈值明显增加。此外，与在侧链中具有巯基的硫醇相比，将巯基移入环中总是导致较高的气味阈值。尽管所有叔硫醇始终表现出较低的气味阈值，但31种化合物均未达到极低的阈值1。同样，没有合成的巯基单萜类化合物具有类似于葡萄柚的类似气味质量。尽管饱和和芳香族类似物的香气与1类似，但大多数其他化合物的香气被描述为含硫，橡胶

  DOI：

  10.1021/acs.jafc.6b01645

文献信息

• REACTIVE COMPOUND
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20150353583A1

  公开（公告）日：2015-12-10

  A reactive compound represented by the following formula (I): [In the formula (I), Z represents a divalent group. A plurality of Y may be the same or different, and represent a monovalent boronate residue having at least one hydroxyl group, Ar 1 and Ar 2 may be the same or different, and represent a trivalent aromatic hydrocarbon group or a trivalent heterocyclic group.].

  由以下公式（I）表示的一种反应性化合物： [在公式（I）中，Z代表二价基团。多个Y可以相同也可以不同，并表示至少有一个羟基的一价硼酸酯残基，Ar1和Ar2可以相同也可以不同，并表示三价芳香烃基团或三价杂环基团。]。
• [EN] BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS<br/>[FR] LIPIDES BIODÉGRADABLES POUR L'ADMINISTRATION D'AGENTS ACTIFS
  申请人：ALNYLAM PHARMACEUTICALS INC

  公开号：WO2013086354A1

  公开（公告）日：2013-06-13

  The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

  本发明涉及一种阳离子脂质，其中在阳离子脂质的脂质部分（例如，疏水链）中具有一个或多个可生物降解的基团。这些阳离子脂质可以掺入脂质粒子中，用于递送一种活性剂，例如核酸。本发明还涉及包含中性脂质、能够减少聚集的脂质、本发明的阳离子脂质以及可选的甾醇的脂质粒子。脂质粒子还可以进一步包括治疗剂，例如核酸。
• ALPHA-SUBSTITUTED VINYLTIN COMPOUND
  申请人：Tatsuta Kuniaki

  公开号：US20090023939A1

  公开（公告）日：2009-01-22

  To provide α-substituted vinyltin useful for the search for function-developing substances such as pharmaceuticals/agrichemicals and functional materials and for the construction of a compound library. An α-substituted vinyltin compound represented by the formula (1), a tautomer or salt of the compound or a solvate thereof: R 2 CH═C(R 3 )Sn(R 1 ) 3 (1) wherein R 1 is a C 1-10 alkyl group, a C 2-14 aryl group or the like, R 2 is a C 2-14 aryl group, a C 2-9 heterocyclyl group, a C 3-10 cycloalkyl group or the like, and R 3 is a carbamoyl group, a thiocarbamoyl group, an isocyanate group, an isothiocyanate group, a formylamino group, a thioformylamino group, an isonitrile group, an urea group, a carbamate group or the like.

  提供α-取代的乙烯基锡，用于寻找功能发展物质，如药物/农药和功能材料，以及用于构建化合物库。由下式表示的α-取代的乙烯基锡化合物（1）或其互变异构体或盐或溶剂合物：R2CH═C(R3)Sn(R1)3（1）其中R1是C1-10烷基，C2-14芳基或类似物，R2是C2-14芳基，C2-9杂环基，C3-10环烷基或类似物，R3是氨基甲酰基，硫氨基甲酰基，异氰酸酯基，异硫氰酸酯基，甲酰氨基基，硫代甲酰氨基基，异腈基，脲基，氨基甲酸酯基或类似物。
• POLYDENTATE LIGAND METAL COMPLEX
  申请人：Kuramochi Yusuke

  公开号：US20120211706A1

  公开（公告）日：2012-08-23

  The present invention provides a metal complex that has excellent durability, and a device and the like having excellent durability that uses such a metal complex. Specifically, the present invention provides a metal complex comprising (a) a polydentate ligand having denticity of five or more that includes a heteroaromatic ring which contains two or more atoms selected from the group consisting of a nitrogen atom, an oxygen atom, and a sulfur atom, and (b) an ion of a metal selected from the group consisting of cerium, praseodymium, ytterbium, and lutetium; a composition comprising the metal complex and a charge transport material; an organic thin film obtained by using the metal complex or composition; and a device obtained by using the metal complex, composition, or organic thin film.

  本发明提供了一种具有优异耐久性的金属配合物，以及使用这种金属配合物的具有优异耐久性的设备等。具体地，本发明提供了一种金属配合物，包括(a)具有五个或更多配位位点的多齿配体，其中包括一个含有来自氮原子、氧原子和硫原子的组成的两个或更多原子的杂环芳香环，以及(b)来自铈、镨、镱和镥等金属的离子；包括所述金属配合物和电荷传输材料的组合物；通过使用金属配合物或组合物获得的有机薄膜；以及通过使用金属配合物、组合物或有机薄膜获得的设备。
• METHOD FOR PRODUCING AROMATIC COMPOUND
  申请人：Sumitomo Chemical Company, Limited

  公开号：US20150322101A1

  公开（公告）日：2015-11-12

  A method is provided for producing an aromatic compound, including a step of mixing a compound represented by formula (A) and a compound represented by formula (B): in the presence of at least one phosphine compound selected from the group consisting of a phosphine represented by formula (C) and a phosphonium salt represented by formula (F): a base, a palladium compound, and an aprotic organic solvent.

  提供一种生产芳香化合物的方法，包括以下步骤：在至少一种磷化物化合物的存在下，将由化学式(A)表示的化合物与由化学式(B)表示的化合物混合；所述磷化物化合物选择自由化学式(C)表示的磷化物和由化学式(F)表示的磷酸盐；还包括碱、钯化合物和无水有机溶剂。