Ethyl 2-[(4-phenylphenyl)methoxymethyl]-1,2,3,6-tetrahydropyridine-5-carboxylate | 186597-72-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Ethyl 2-[(4-phenylphenyl)methoxymethyl]-1,2,3,6-tetrahydropyridine-5-carboxylate
• CAS: 186597-72-8
• 化学式: C₂₂H₂₅NO₃
• 分子量: 351.445
• InChiKey: JWINUVCJZHJYBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Ethyl 2-[(4-phenylphenyl)methoxymethyl]-1,2,3,6-tetrahydropyridine-5-carboxylate 在 盐酸 作用下， 以 溶剂黄146 为溶剂， 以51%的产率得到2-[(4-Phenylphenyl)methoxymethyl]-1,2,3,6-tetrahydropyridine-5-carboxylic acid
  参考文献：
  名称：

  6-(4-Phenyl-benzyloxy-methyl) guvacine. Synthesis, GABA uptake inhibitor and muscarinic properties

  摘要：

  6-(4-Phenyl-benzyloxy-methyl) guvacine was synthesized. Surprisingly the compound was devoid of the gamma-aminobutyric acid (GABA) uptake inhibitory activity of its parent compound guvacine, but instead showed affinities for the muscarinic M(1) and M(2) receptors. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0960-894x(96)00562-8
• 作为产物：
  描述：

  2,5-吡啶二甲酸二乙酯 在 sodium tetrahydroborate 、 1-氯乙基氯甲酸酯 、 sodium hydride 、 calcium chloride 作用下， 以 甲醇 、 1,2-二氯乙烷 、 N,N-二甲基甲酰胺 、 丙酮 、 乙腈 为溶剂， 生成 Ethyl 2-[(4-phenylphenyl)methoxymethyl]-1,2,3,6-tetrahydropyridine-5-carboxylate
  参考文献：
  名称：

  6-(4-Phenyl-benzyloxy-methyl) guvacine. Synthesis, GABA uptake inhibitor and muscarinic properties

  摘要：

  6-(4-Phenyl-benzyloxy-methyl) guvacine was synthesized. Surprisingly the compound was devoid of the gamma-aminobutyric acid (GABA) uptake inhibitory activity of its parent compound guvacine, but instead showed affinities for the muscarinic M(1) and M(2) receptors. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0960-894x(96)00562-8

文献信息

• 6-(4-Phenyl-benzyloxy-methyl) guvacine. Synthesis, GABA uptake inhibitor and muscarinic properties
  作者：Philippe Bisel、Jean Pierre Gies、Gilbert Schlewer、Camille G. Wermuth

  DOI：10.1016/s0960-894x(96)00562-8

  日期：1996.12

  6-(4-Phenyl-benzyloxy-methyl) guvacine was synthesized. Surprisingly the compound was devoid of the gamma-aminobutyric acid (GABA) uptake inhibitory activity of its parent compound guvacine, but instead showed affinities for the muscarinic M(1) and M(2) receptors. Copyright (C) 1996 Elsevier Science Ltd