2-Benzyl-4,7-dimethoxy-benzimidazol | 457050-37-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-Benzyl-4,7-dimethoxy-benzimidazol
• 英文别名: 2-benzyl-4,7-dimethoxy-1H-benzoimidazole；2-Benzyl-4,7-dimethoxybenzimidazole；2-benzyl-4,7-dimethoxy-1H-benzimidazole
• CAS: 457050-37-2
• 化学式: C₁₆H₁₆N₂O₂
• 分子量: 268.315
• InChiKey: XMJMYFYBMKWGOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  47.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Benzyl-4,7-dimethoxy-benzimidazol 在 盐酸 、 potassium dichromate 、 氢溴酸 、 sodium hydride 作用下， 以 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 17.5h， 生成 1,2-Dibenzylbenzimidazole-4,7-dione
  参考文献：
  名称：

  Benzimidazole-4,7-diones as Inhibitors of Protozoal ( Toxoplasma gondii ) Purine Nucleoside Phosphorylase

  摘要：

  Ben zimidazole-4,7-diones derivatives substituted at 1- and/or 2-position have been synthetized and tested as inhibitors of purine nucleoside phosphorylase (PNP), isolated from two strains of Toxoplasma gondii (RH and ME 49). They were identified as inhibitors of both enzymes. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00064-1
• 作为产物：
  描述：

  1,4-二甲氧基-2,3-二硝基苯 在 盐酸 、 tin 作用下， 反应 7.0h， 生成 2-Benzyl-4,7-dimethoxy-benzimidazol
  参考文献：
  名称：

  Benzimidazole-4,7-diones as Inhibitors of Protozoal ( Toxoplasma gondii ) Purine Nucleoside Phosphorylase

  摘要：

  Ben zimidazole-4,7-diones derivatives substituted at 1- and/or 2-position have been synthetized and tested as inhibitors of purine nucleoside phosphorylase (PNP), isolated from two strains of Toxoplasma gondii (RH and ME 49). They were identified as inhibitors of both enzymes. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00064-1

文献信息

• Benzimidazole-4,7-diones as Inhibitors of Protozoal ( Toxoplasma gondii ) Purine Nucleoside Phosphorylase
  作者：Frédéric Alvarez、Arnaud Ghérardi、Pascal Nebois、Marie-Elizabeth Sarciron、Anne-Françoise Pétavy、Nadia Walchshofer

  DOI：10.1016/s0960-894x(02)00064-1

  日期：2002.3

  Ben zimidazole-4,7-diones derivatives substituted at 1- and/or 2-position have been synthetized and tested as inhibitors of purine nucleoside phosphorylase (PNP), isolated from two strains of Toxoplasma gondii (RH and ME 49). They were identified as inhibitors of both enzymes. (C) 2002 Elsevier Science Ltd. All rights reserved.