N-dodecanoyl-DL-norleucine | 97850-53-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-dodecanoyl-DL-norleucine
• 英文别名: N-lauroyl-norleucine；N-Lauroyl-norleucin；N-lauroylaminohexanoic acid；2-(dodecanoylamino)hexanoic acid
• CAS: 97850-53-8
• 化学式: C₁₈H₃₅NO₃
• 分子量: 313.481
• InChiKey: GWINZSOQDIOTTN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  22
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-dodecanoyl-DL-norleucine 在 氯化亚砜 、 磺酰氯 作用下， 生成 2-chloro-6-lauroylamino-hexanoic acid
  参考文献：
  名称：

  DE949568

  摘要：

  公开号：
• 作为产物：
  描述：

  月桂酰氯 、 DL-正亮氨酸 在 sodium hydroxide 作用下， 生成 N-dodecanoyl-DL-norleucine
  参考文献：
  名称：

  The Preparation of Long Chain N-Acylamino Acids

  摘要：

  DOI：

  10.1021/ja01582a049

文献信息

• New polymer materials for contact lens applications
  申请人：CIS Pharma AG

  公开号：US20200283560A1

  公开（公告）日：2020-09-10

  The present invention relates to copolymers made from a polymerization mixture comprising (a) one or more polymerizable monomers, which monomers are characterized as having at least one vinylic group and not containing an amino acid residue, (b) one or more not-functionalized side chain-linked amino acids, (c) one or more functionalized side chain-linked amino acids, (d) a free radical initiator and, optionally, (e) a chain-transfer-agent. It also relates to block copolymers comprising the same monomers. The invention also encompasses silicone hydrogel contact lenses coated with or comprising the latter copolymers and block copolymers as well methods for introducing the copolymers and block copolymers into silicone hydrogel contact lenses.

  本发明涉及由聚合混合物制成的共聚物，所述聚合混合物包括（a）一种或多种可聚合单体，该单体被表征为至少具有一个乙烯基团且不含氨基酸残基，（b）一种或多种未功能化的侧链连接的氨基酸，（c）一种或多种功能化的侧链连接的氨基酸，（d）自由基引发剂，以及可选地，（e）链转移剂。还涉及包含相同单体的嵌段共聚物。该发明还涵盖涂有或包含后述共聚物和嵌段共聚物的硅水凝胶隐形眼镜，以及将这些共聚物和嵌段共聚物引入硅水凝胶隐形眼镜的方法。
• Pigment consisting of polyvalent metal salt of acylated amino acid or
  申请人：Kao Corporation

  公开号：US05167709A1

  公开（公告）日：1992-12-01

  A pigment consisting of a polyvalent metal salt of an amidosulfonic acid represented by the following general formula (I): ##STR1## wherein R.sup.1 represents a straight-chain or branched alkyl, alkenyl or hydroxyalkyl group each having 7 to 21 carbon atoms; R.sup.2 represents a hydrogen atom or a methyl group; X represents an ethylene group, a propylene group or a ##STR2## M represents a polyvalent metal atom; m represents the valence of M: and n is an integer of from 1 to 4; and a pigment consisting of a polyvalent metal salt of an acylated amino acid represented by the following general formula (II): ##STR3## wherein R.sup.1 represents a straight-chain or branched alkyl, alkenyl or hydroxyalkyl group each having 7 to 21 carbon atoms; y represents a number selected from among 1, 2, 3, 4, 5, 10, and 11; M represents a polyvalent metal atom; m represents the valence of M: and n is an integer of from 1 to 4; as well as cosmetic compositions containing these pigments are disclosed.

  本发明揭示了一种颜料，其中包括以下通式（I）所代表的酰氨基磺酸多价金属盐：##STR1## 其中，R1代表直链或支链烷基，烯基或羟基烷基，每个碳原子数为7到21个；R2代表氢原子或甲基基团；X代表乙烯基，丙烯基或##STR2## M代表多价金属原子；m代表M的价；n为1到4的整数。本发明还揭示了一种颜料，其中包括以下通式（II）所代表的酰化氨基酸多价金属盐：##STR3## 其中，R1代表直链或支链烷基，烯基或羟基烷基，每个碳原子数为7到21个；y代表选自1、2、3、4、5、10和11的数字；M代表多价金属原子；m代表M的价；n为1到4的整数。此外，本发明还揭示了含有这些颜料的化妆品组合物。
• Pigment consisting of polyvalent metal salt of amidosulfonic acid and cosmetic composition containing the same
  申请人：KAO CORPORATION

  公开号：EP0455018A1

  公开（公告）日：1991-11-06

  sA pigment consisting of a polyvalent metal salt of an amidosulfonic acid represented by the following general formula (I):    wherein R¹ represents a straight-chain or branched alkyl, alkenyl or hydroxyalkyl group each having 7 to 21 carbon atoms; R²represents a hydrogen atom or a methyl group; Xrepresents an ethylene group, a propylene group or Mrepresents a polyvalent metal atom; mrepresents the valence of M: and nis an integer of from 1 to 4; and a pigment consisting of a polyvalent metal salt of an acylated amino acid represented by the following general formula (II):    wherein R¹ represents a straight-chain or branched alkyl, alkenyl or hydroxyalkyl group each having 7 to 21 carbon atoms; Yrepresents a number selected from among 1, 2, 3, 4, 5, 10, and 11; Mrepresents a polyvalent metal atom; mrepresents the valence of M: and nis an integer of from 1 to 4; as well as cosmetic compositions containing these pigments are disclosed.

  由以下通式 (I) 所代表的脒基磺酸的多价金属盐组成的颜料： 其中 R¹ 代表直链或支链烷基、烯基或羟基烷基，每个烷基具有 7 至 21 个碳原子； R² 代表氢原子或甲基； X代表乙烯基团、丙烯基团或 M 代表多价金属原子； m 代表 M 的化合价 n 是 1 至 4 的整数；以及 由以下通式(II)代表的酰化氨基酸的多价金属盐组成的颜料： 其中 R¹ 代表直链或支链烷基、烯基或羟基烷基，每个烷基具有 7 至 21 个碳原子； Y 代表从 1、2、3、4、5、10 和 11 中选出的数字； M 代表多价金属原子； m 代表 M 的化合价 n 是 1 至 4 的整数； 以及含有这些颜料的化妆品成分。
• Polymer materials for contact lens applications
  申请人：CIS Pharma AG

  公开号：US11008414B2

  公开（公告）日：2021-05-18

  The present invention relates to copolymers made from a polymerization mixture comprising (a) one or more polymerizable monomers, which monomers are characterized as having at least one vinylic group and not containing an amino acid residue, (b) one or more not-functionalized side chain-linked amino acids, (c) one or more functionalized side chain-linked amino acids, (d) a free radical initiator and, optionally, (e) a chain-transfer-agent. It also relates to block copolymers comprising the same monomers. The invention also encompasses silicone hydrogel contact lenses coated with or comprising the latter copolymers and block copolymers as well methods for introducing the copolymers and block copolymers into silicone hydrogel contact lenses.

  本发明涉及由聚合混合物制成的共聚物，聚合混合物包括(a)一种或多种可聚合单体，这些单体的特征是至少有一个乙烯基且不含氨基酸残基，(b)一种或多种未官能化的侧链连接氨基酸，(c)一种或多种官能化的侧链连接氨基酸，(d)自由基引发剂，以及可选的(e)链转移剂。本发明还涉及由相同单体组成的嵌段共聚物。本发明还包括涂有或包含后一种共聚物和嵌段共聚物的硅水凝胶隐形眼镜，以及将共聚物和嵌段共聚物引入硅水凝胶隐形眼镜的方法。
• US5167709A
  申请人：——

  公开号：US5167709A

  公开（公告）日：1992-12-01