Carbonic acid tert-butyl ester phenoxymethyl ester | 920967-23-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Carbonic acid tert-butyl ester phenoxymethyl ester
• 英文别名: tert-Butyl phenoxymethyl carbonate
• CAS: 920967-23-3
• 化学式: C₁₂H₁₆O₄
• 分子量: 224.257
• InChiKey: TZCYARAYCBOFEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  氯甲基叔丁基碳酸酯 在 四丁基硫酸氢铵 、 碳酸氢钠 、 potassium carbonate 、 sodium iodide 作用下， 以 二氯甲烷 、 水 、 丙酮 为溶剂， 生成 Carbonic acid tert-butyl ester phenoxymethyl ester
  参考文献：
  名称：

  克服烷氧基羰基氧基甲基（AOCOM）卤化物与酚类偶联反应中的空间效应：AOCOM酚类前药的有效合成

  摘要：

  立体位阻是AOCOM卤化物与酚类偶联反应的关键因素。立体上不受阻碍的烷氧基有利于酰化苯酚的形成。在相转移条件下，无论空间位阻如何，烷基化苯酚都是有利的。

  DOI：

  10.1016/j.tetlet.2006.10.160

文献信息

• SUBSTITUTED 1,3-DIOXANES USEFUL AS PPAR MODULATORS
  申请人：Evolva SA

  公开号：EP2150111B1

  公开（公告）日：2016-10-19
• PRODRUGS OF SUBSTITUTED 1,3-DIOXANES AND THEIR USES
  申请人：Alberts Peteris

  公开号：US20100087517A1

  公开（公告）日：2010-04-08

  The present invention relates to prodrugs of compounds containing 1,3-dioxane moiety, pharmaceutical compositions thereof, and the use of the compounds and compositions for the modulation of thromboxane A2 or a peroxisome proliferator-activated receptor. The prodrugs of the compounds, analogs, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions can be used in the treatment and prevention of cancer.
• SUBSTITUTED 1,3-DIOXANES AND THEIR USES
  申请人：Sorensen Alexandra Santana

  公开号：US20100273824A1

  公开（公告）日：2010-10-28

  The present invention relates to compounds containing 1,3-dioxane moiety, pharmaceutical compositions thereof, and the use of the compounds and compositions for the modulation of thromboxane A2 or a peroxisome proliferator-activated receptor. The compounds, analogs, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions can be used in the treatment and prevention of cancer.
• 1,3-Dioxanes and Their Uses
  申请人：Sorensen Alexandra Santana

  公开号：US20120252836A1

  公开（公告）日：2012-10-04

  The present invention relates to compounds containing 1,3-dioxane moiety, pharmaceutical compositions thereof, and the use of the compounds and compositions for the modulation of thromboxane A2 or a peroxisome proliferator-activated receptor. The compounds, analogs, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions can be used in the treatment and prevention of cancer.
• Substituted 1,3-Dioxanes and There Uses
  申请人：Sorensen Alexandra Santana

  公开号：US20130197030A1

  公开（公告）日：2013-08-01

  The present invention relates to compounds containing 1,3-dioxane moiety, pharmaceutical compositions thereof, and the use of the compounds and compositions for the modulation of thromboxane A2 or a peroxisome proliferator-activated receptor. The compounds, analogs, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions can be used in the treatment and prevention of cancer.