Adipinsaeure-bis--ester | 6668-00-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Adipinsaeure-bis--ester
• 英文别名: Adipinsaeure-bis-(aethoxycarbonyl)-ester；Bis(ethoxycarbonyl) hexanedioate；bis(ethoxycarbonyl) hexanedioate
• CAS: 6668-00-4
• 化学式: C₁₂H₁₈O₈
• 分子量: 290.27
• InChiKey: MQRKTEGDHZOEML-UHFFFAOYSA-N

物化性质

• 沸点：
  366.9±52.0 °C(Predicted)
• 密度：
  1.206±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  20
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  105
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  Adipinsaeure-bis--ester 、 苯胺 生成 己二酰二苯胺
  参考文献：
  名称：

  Proximity Effects in the Decomposition of Mixed Dicarboxylic—Carbonic Anhydrides

  摘要：

  DOI：

  10.1021/jo01033a055
• 作为产物：
  描述：

  己二酸 、 氯甲酸乙酯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 生成 Adipinsaeure-bis--ester
  参考文献：
  名称：

  一系列双插双蒽环类化合物的合成与表征

  摘要：

  据报道，双-柔红霉素衍生物（5a - g）的合成已被证明可以作为DNA的双插层剂，并且还具有缓慢的DNA分解动力学。

  DOI：

  10.1039/c39860000659

文献信息

• A METHOD OF MODIFICATION OF HYALURONIC ACID BY MEANS OF (O-ACYL-O'-ALKYL CARBONATE - SUBSTITUTED PYRIDINE) COMPLEX
  申请人：Contipro C A.S.

  公开号：EP2408823A1

  公开（公告）日：2012-01-25
• Method of Modification of Hyaluronic Acid by Means of (O-ACYL-O'-ALKYL Carbonate-Substituted Pyridine) Complex
  申请人：Buffa Radovan

  公开号：US20120095205A1

  公开（公告）日：2012-04-19

  This invention relates to a novel method of preparation of hyaluronic acid derivatives by means of a reaction of the hyaluronic acid with the complex (O-acyl-O′-alkyl carbonate-substituted pyridine) of the general formula R—CO—O—CO—O—R1 and R25C5N. The reaction takes place in DMSO in the presence of an external base, forming O-acylated products. The method leads to higher substitution degrees and shorter reaction times compared to the known analogues, hi case the agent comprises two or more functional groups R(CO—O—CO—O—R1)n, crosslinked hyaluronic acid derivatives are formed.
• [EN] A METHOD OF MODIFICATION OF HYALURONIC ACID BY MEANS OF (O-ACYL-O'-ALKYL CARBONATE - SUBSTITUTED PYRIDINE) COMPLEX<br/>[FR] PROCÉDÉ DE MODIFICATION DE L'ACIDE HYALURONIQUE PAR UN COMPLEXE (CARBONATE D'O-ACYL-O'-ALKYLE - PYRIDINE SUBSTITUÉE)
  申请人：CONTIPRO C A S

  公开号：WO2010105582A1

  公开（公告）日：2010-09-23

  This invention relates to a novel method of preparation of hyaluronic acid derivatives by means of a reaction of the hyaluronic acid with the complex (O-acyl-O'-alkyl carbonate -substituted pyridine) of the general formula R-CO-O-CO-O-R1 and R25C5N. The reaction takes place in DMSO in the presence of an external base, forming O-acylated products. The method leads to higher substitution degrees and shorter reaction times compared to the known analogues, hi case the agent comprises two or more functional groups R(CO-O-CO-O-R1 )n, crosslinked hyaluronic acid derivatives are formed.