methacrylic acid decahydro-[2]naphthyl ester | 46719-03-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methacrylic acid decahydro-[2]naphthyl ester
• 英文别名: Opt.-inakt. 2-Methacryloyloxy-decahydro-naphthalin；Methacrylsaeure-decahydro-[2]naphthylester；(Decahydro-naphthyl-(2))-methacrylat；2-Methacryloyloxy-decalin；1,2,3,4,4a,5,6,7,8,8a-Decahydronaphthalen-2-yl 2-methylprop-2-enoate
• CAS: 46719-03-3
• 化学式: C₁₄H₂₂O₂
• 分子量: 222.327
• InChiKey: ZRALIWYADDIULD-UHFFFAOYSA-N

物化性质

• 沸点：
  298.3±9.0 °C(Predicted)
• 密度：
  0.99±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  甲基丙烯酸甲酯 、 (2R*,4aS*,8aR*)-decahydro-2-naphthol 生成 methacrylic acid decahydro-[2]naphthyl ester
  参考文献：
  名称：

  Esters of methacrylic acid

  摘要：

  公开号：

  US02129666A1

文献信息

• Thromboresistant materials incorporating pyrazinone protease inhibitors
  申请人：——

  公开号：US20010021713A1

  公开（公告）日：2001-09-13

  Thromboresistant materials are described which incorporate pyrazinone compounds of the Formula I: 1 wherein X is O, NR 11 or CH=N, R 3 -R 11 , R a , R b , R c , W, m, and n are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof. The compounds of the invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, thrombin, plasmin and factor Xa. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin. Compositions for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation are described. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage, such as catheters, blood dialysis machines, blood collection syringes and tubes, blood lines and stents. Additionally, the compounds can be detectably labeled and employed for in vivo imaging of thrombi.

  本发明提供了一种含有Formula I的吡唑酮化合物的抗血栓材料：1其中X为O、NR11或CH= N，R3-R11、Ra、Rb、Rc、W、m和n在规范中设置，以及其水合物、溶剂化合物或药学上可接受的盐。本发明的化合物是蛋白酶的强效抑制剂，特别是胰蛋白酶样丝氨酸蛋白酶，如凝血酶、血纤维蛋白溶解酶和Xa因子。其中某些化合物通过直接、选择性地抑制凝血酶表现出抗血栓活性。本发明还描述了用于抑制血小板损失、抑制血小板聚集、抑制纤维蛋白形成、抑制血栓形成和抑制栓子形成的组合物。本发明的化合物的其他用途是作为抗凝剂嵌入或物理链接到用于血液收集、血液循环和血液储存的设备中，如导管、血液透析机、血液采集注射器和管道、血管支架等。此外，这些化合物可以被检测标记并用于体内血栓的成像。
• Gram negative bacteruria test
  申请人：MILES INC.

  公开号：EP0224830A2

  公开（公告）日：1987-06-10

  A screening method for the determination of 10⁴ gram negative bacteria per milliliter of an undiluted urine sample and a unitary screening test device for the determination of at least 10⁵ gram negative bacteria per milliliter of an undiluted urine sample. The method and test device make use of Limulus amebocyte lysate (LAL) and a synthetic substrate containing a chromogenic or fluorogenic leaving group capable of being cleaved by activated lysate. This screening method and unitary screening device provide a quick, convenient, inexpensive indication of the possible presence of a urinary tract infection caused by gram negative bacteria.

  一种用于测定每毫升未稀释尿液样本中 10 ⁴ 个革兰氏阴性细菌的筛查方法，以及一种用于测定每毫升未稀释尿液样本中至少 10 ⁵ 个革兰氏阴性细菌的单元筛查测试装置。该方法和检测装置使用了嗜酸性粒细胞裂解液（LAL）和一种合成底物，该底物含有可被活化裂解液裂解的发色或发荧光的离去基团。这种筛查方法和单一的筛查装置可快速、方便、廉价地显示是否存在由革兰氏阴性细菌引起的尿路感染。
• PIGMENT DISPERSION INCLUDING AZO PIGMENT AND AQUEOUS INK FOR INKJET RECORDING USING THE SAME
  申请人：FUJIFILM Corporation

  公开号：EP2474580A1

  公开（公告）日：2012-07-11

  The invention provides pigment dispersion capable of preparing aqueous ink for inkjet recording, the particle size of which is not changed after storage for a long period of time or even after being exposed to a high temperature condition, generation of streaks and unevenness are controlled, which aqueous ink is capable of forming uniform printed images excellent in light fastness. Another object is to provide aqueous ink for inkjet recording using the pigment dispersion. A pigment dispersion including vinyl polymer particles containing A and B: A: an azo pigment represented by the following formula (1), a tautomer thereof, a salt thereof, a hydrate thereof, or a solvate thereof, B: a vinyl polymer containing a structural unit (a) having a non-aromatic alicyclic group bonded to the polymer main chain via a linking group, and a structural unit (b) having a hydrophilic group, wherein Q represents a nonmetallic atomic group necessary to form a 5-, 6- or 7-membered heterocyclic ring together with a carbon atom; W represents an alkoxy group, an amino group, an alkyl group or an aryl group; each of X1 and X2 independently represents a hydrogen atom, an alkyl group, an acyl group, an alkylsulfonyl group, or an arylsulfonyl group; R1 represents a hydrogen atom or a substituent; R2 represents a heterocyclic group; n represents an integer of 1 to 4, and when n is 2, formula (1) represents a dimer via Q, W. X1, X2, R1 or R2, when n is 3, formula (1) represents a trimer via Q, W, X1, X2, R1 or R2, and when n is 4, formula (1) represents a tetramer via Q, W, X1, X2, R1 or R2.

  本发明提供了能够制备喷墨记录用水性墨水的颜料分散体，这种水性墨水的粒径在长期储存甚至暴露在高温条件下后都不会发生变化，条纹和不均匀的产生也得到了控制，这种水性墨水能够形成光牢度极佳的均匀印刷图像。另一个目的是提供使用该颜料分散体的喷墨记录水性墨水。 颜料分散体包括含有 A 和 B 的乙烯基聚合物颗粒： A：由下式（1）表示的偶氮颜料、其同系物、其盐、其水合物或其溶液、 B：乙烯基聚合物，含有通过连接基团与聚合物主链结合的具有非芳香脂环基的结构单元 (a) 和具有亲水基团的结构单元 (b)、 其中 Q 代表与碳原子一起形成 5、6 或 7 元杂环所需的非金属原子团；W 代表烷氧基、氨基、烷基或芳基；X1 和 X2 各自独立地代表氢原子、烷基、酰基、烷基磺酰基或芳基磺酰基； R1 代表氢原子或取代基； R2 代表杂环基； n 代表 1 至 4 的整数，当 n 为 2 时，式（1）通过 Q、W 代表二聚体。X1、X2、R1 或 R2 表示二聚体；当 n 为 3 时，式 (1) 通过 Q、W、X1、X2、R1 或 R2 表示三聚体；当 n 为 4 时，式 (1) 通过 Q、W、X1、X2、R1 或 R2 表示四聚体。
• ORGANOPOLYSILOXANE GRAFT POLYMER
  申请人：Kao Corporation

  公开号：EP2927253A1

  公开（公告）日：2015-10-07

  The present invention relates to an organopolysiloxane graft polymer including an organopolysiloxane segment as a main chain thereof and an unsaturated monomer-derived polymer segment as a side chain thereof, in which a content of the organopolysiloxane segment in the organopolysiloxane graft polymer is not less than 35% by mass and not more than 70% by mass, and the unsaturated monomer-derived polymer segment contains a repeating unit derived from a nonionic unsaturated monomer having a glass transition temperature Tg of 60°C or higher (except for a repeating unit derived from an unsaturated monomer containing an amino group) in an amount of not less than 40% by mass and not more than 90% by mass, and further contains a repeating unit derived from a cationic unsaturated monomer in an amount of not less than 10% by mass and not more than 60% by mass.

  本发明涉及一种有机聚硅氧烷接枝聚合物，包括作为其主链的有机聚硅氧烷段和作为其侧链的不饱和单体衍生聚合物段，其中有机聚硅氧烷段在有机聚硅氧烷接枝聚合物中的含量不低于35%（质量百分比）且不超过70%（质量百分比）、不饱和单体衍生的聚合物段含有由玻璃化转变温度 Tg 为 60°C 或更高的非离子不饱和单体衍生的重复单元（由含有氨基的不饱和单体衍生的重复单元除外），其含量不低于 40%（按质量计）且不超过 90%（按质量计），还含有由阳离子不饱和单体衍生的重复单元，其含量不低于 10%（按质量计）且不超过 60%（按质量计）。
• CURABLE LIQUID/LIQUID/SOLID MULTIPHASIC SUSPENSIONS
  申请人：3M Innovative Properties Company

  公开号：EP4098444A1

  公开（公告）日：2022-12-07

  The present invention relates to curable compositions comprising a plurality of particles, a primary liquid phase comprising at least one polymerizable or cross-linkable organic compound that can form organic polymers or networks, and a secondary liquid phase.

  本发明涉及可固化组合物，该组合物包括多个颗粒、由至少一种可形成有机聚合物或网络的可聚合或可交联有机化合物组成的一级液相以及二级液相。