Phenylalanin-<4-chlor-anilid> | 97437-86-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Phenylalanin-<4-chlor-anilid>
• 英文别名: Phe-p-chloranilid；2-amino-N-(4-chlorophenyl)-3-phenylpropanamide
• CAS: 97437-86-0
• 化学式: C₁₅H₁₅ClN₂O
• 分子量: 274.75
• InChiKey: ULCFISDATRSWOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-氯苯胺盐酸盐 、 4-苄基噁唑烷-2,5-二酮 生成 Phenylalanin-<4-chlor-anilid>
  参考文献：
  名称：

  的反应749. Ñ羧基- α -氨基-酸酐与羟胺盐酸盐的，Ó -alkylhydroxylamines，和胺; 氨基异羟肟酸，酰胺基氧肽和α-氨基酸酰胺的合成

  摘要：

  DOI：

  10.1039/jr9640003941

文献信息

• Compounds and Methods for Treating Mammalian Gastrointestinal Microbial Infections
  申请人：Hedstrom Lizbeth K.

  公开号：US20120101096A1

  公开（公告）日：2012-04-26

  Described herein are compounds, and pharmaceutically acceptable salts and prodrugs thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound of the invention selectively inhibits a parasitic IMPDH versus a host IMPDH. Further, the invention provides pharmaceutical compositions comprising one or more compounds of the invention. The invention also relates to methods of treating various parasitic and bacterial infections in mammals. Moreover, the compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.

  本文描述了一些化合物，以及其药用盐和前药，这些化合物可用作IMPDH的抑制剂。在某些实施例中，本发明的化合物选择性地抑制寄生物IMPDH而不抑制宿主IMPDH。此外，本发明提供了包含一种或多种本发明化合物的药物组合物。本发明还涉及治疗哺乳动物中各种寄生虫和细菌感染的方法。此外，这些化合物可以单独使用或与其他治疗或预防剂（如抗病毒药物、抗炎药物、抗微生物药物和免疫抑制剂）结合使用。
• [EN] NAPHTHOQUINONE OXIME COMPOUND, PREPARATION METHOD THEREFOR, AND USES THEREOF<br/>[FR] COMPOSÉ DE NAPHTOQUINONE OXIME, SON PROCÉDÉ DE PRÉPARATION ET SES APPLICATIONS<br/>[ZH] 肟基萘醌类化合物及其制备方法和用途
  申请人：SEASONS BIOTECHNOLOGY TAIZHOU CO LTD

  公开号：WO2020082817A1

  公开（公告）日：2020-04-30

  本申请属于药物化合物和药物技术领域，涉及肟基萘醌类化合物及其制备方法和用途，具体涉及式(I)的化合物，该化合物能够作为STAT3和IDO1的双靶点选择性抑制剂，其用于治疗卵巢癌、结肠癌及肺癌等
• Compounds and Methods for Treating Mammalian Gastrointestinal Parasitic Infections
  申请人：Hedstrom Lizbeth K.

  公开号：US20100022547A1

  公开（公告）日：2010-01-28

  One aspect of the present invention relates to compounds, and pharmaceutically acceptable salts and prodrugs thereof, that are useful as inhibitors of IMPDH. The invention also provides pharmaceutical compositions comprising the compounds of the invention which selectively inhibit parasitic IMPDH. In certain embodiments, the present invention relates to selective inhibition of C. parvum inosine-5′-monophosphate-dehydrogenase over human inosine-5′-monophosphate-dehydrogenase (IMPDH type I and type II). These compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
• US8969342B2
  申请人：——

  公开号：US8969342B2

  公开（公告）日：2015-03-03
• [EN] COMPOUNDS AND METHODS FOR TREATING MAMMALIAN GASTROINTESTINAL PARASITIC INFECTIONS<br/>[FR] COMPOSÉS ET PROCÉDÉS DE TRAITEMENT DES INFECTIONS PARASITAIRES GASTRO-INTESTINALES DES MAMMIFÈRES
  申请人：BRANDEIS UNIVERSITY MS134

  公开号：WO2007143557A2

  公开（公告）日：2007-12-13

  [EN] One aspect of the present invention relates to compounds, and pharmaceutically acceptable salts and prodrugs thereof, that are useful as inhibitors of IMPDH. The invention also provides pharmaceutical compositions comprising the compounds of the invention which selectively inhibit parasitic IMPDH. In certain embodiments, the present invention relates to selective inhibition of C. parvum inosine-5'-monophosphate-dehydrogenase over human inosine-5'-monophosphate-dehydrogenase (IMPDH type I and type II). These compounds may be used alone or in combination with other therapeutic or prophylactic agents, such as anti-virals, anti-inflammatory agents, antimicrobials and immunosuppressants.
  [FR] Selon un premier aspect, la présente invention concerne des composés et leurs sels et promédicaments pharmaceutiquement acceptables qui sont utilisables en tant qu'inhibiteurs de l'IMPDH. L'invention concerne également des compositions pharmaceutiques comprenant les composés de l'invention qui inhibent sélectivement l'IMPDH de parasites. Selon certains modes de réalisation, la présente invention concerne l'inhibition sélective de l'inosine-5'-monophosphate-déshydrogénase de Cryptosporidium parvum de préférence à l'inosine-5'-monophosphate-déshydrogénase humaine (IMPDH de type I et de type II). Ces composés peuvent être utilisés seuls ou en combinaison avec d'autres agents thérapeutiques ou prophylactiques tels que des antiviraux, des agents anti-inflammatoires, des antimicrobiens et des immunosuppresseurs.