(2S)-2-[bis(prop-2-enyl)amino]-N',2-diphenylacetohydrazide | 890657-46-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-[bis(prop-2-enyl)amino]-N',2-diphenylacetohydrazide
• CAS: 890657-46-2
• 化学式: C₂₀H₂₃N₃O
• 分子量: 321.422
• InChiKey: ZMFFJSBOLBAEFB-IBGZPJMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  24
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  44.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2S)-2-[bis(prop-2-enyl)amino]-N',2-diphenylacetohydrazide 在 四氯化碳 、 三苯基膦 作用下， 以 乙腈 为溶剂， 反应 12.0h， 生成
  参考文献：
  名称：

  Stereoselective intramolecular cycloadditions of homochiral nitrilimines as a source of enantiopure 2,3,3a,4,5,6-hexahydro-pyrrolo[3,4-c]pyrazoles

  摘要：

  Starting from the methyl esters of glycine, L-alanine.. L-phenylalanine and (S)-2-phenylglycine, we developed a synthetic route to the title compounds in the enantiopure form by means of a stereoselective intramolecular 1,3-dipolar cycloaddition of homochiral nitrilimines 5a-d. Fair to good overall product yields and high cycloaddition diastereoselectivity were obtained. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.02.018
• 作为产物：
  描述：

  甲基2-(苯基氨基)乙酸酯 在 sodium hydroxide 、 三乙胺 作用下， 以 四氢呋喃 、 水 、 甲苯 为溶剂， 反应 15.0h， 生成 (2S)-2-[bis(prop-2-enyl)amino]-N',2-diphenylacetohydrazide
  参考文献：
  名称：

  Stereoselective intramolecular cycloadditions of homochiral nitrilimines as a source of enantiopure 2,3,3a,4,5,6-hexahydro-pyrrolo[3,4-c]pyrazoles

  摘要：

  Starting from the methyl esters of glycine, L-alanine.. L-phenylalanine and (S)-2-phenylglycine, we developed a synthetic route to the title compounds in the enantiopure form by means of a stereoselective intramolecular 1,3-dipolar cycloaddition of homochiral nitrilimines 5a-d. Fair to good overall product yields and high cycloaddition diastereoselectivity were obtained. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.02.018

文献信息

• Stereoselective intramolecular cycloadditions of homochiral nitrilimines as a source of enantiopure 2,3,3a,4,5,6-hexahydro-pyrrolo[3,4-c]pyrazoles
  作者：Lara De Benassuti、Paola Del Buttero、Giorgio Molteni

  DOI：10.1016/j.tetasy.2006.02.018

  日期：2006.3

  Starting from the methyl esters of glycine, L-alanine.. L-phenylalanine and (S)-2-phenylglycine, we developed a synthetic route to the title compounds in the enantiopure form by means of a stereoselective intramolecular 1,3-dipolar cycloaddition of homochiral nitrilimines 5a-d. Fair to good overall product yields and high cycloaddition diastereoselectivity were obtained. (c) 2006 Elsevier Ltd. All rights reserved.