(2S)-[(2,2-dimethylpropanoyl)amino](phenyl)acetic acid | 915280-39-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-[(2,2-dimethylpropanoyl)amino](phenyl)acetic acid
• 英文别名: (R)-2-phenyl-2-pivalamidoacetic acid；(2S)-2-(2,2-dimethylpropanoylamino)-2-phenylacetic acid
• CAS: 915280-39-6
• 化学式: C₁₃H₁₇NO₃
• 分子量: 235.283
• InChiKey: UYMYKMRRCXEIRJ-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2S)-[(2,2-dimethylpropanoyl)amino](phenyl)acetic acid 、 四丁基氢氧化铵 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and enantiomeric recognition studies of a novel 5,5-dioxophenothiazine-1,9 bis(thiourea) containing glucopyranosyl groups

  摘要：

  A novel optically active 5,5-dioxophenothiazine-1,9 bis(thiourea) containing glucopyranosyl groups was synthesized and its enantiomeric recognition properties were examined towards the enantiomers of tetrabutylammonium salts of chiral alpha-hydroxy and N-protected alpha-amino acids using UV-vis spectroscopy. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2012.11.020
• 作为产物：
  描述：

  L-苯甘氨酸 、 三甲基乙酰氯 在 sodium hydroxide 、 盐酸 作用下， 以 水 为溶剂， 以38%的产率得到(2S)-[(2,2-dimethylpropanoyl)amino](phenyl)acetic acid
  参考文献：
  名称：

  Synthesis and enantiomeric recognition studies of a novel 5,5-dioxophenothiazine-1,9 bis(thiourea) containing glucopyranosyl groups

  摘要：

  A novel optically active 5,5-dioxophenothiazine-1,9 bis(thiourea) containing glucopyranosyl groups was synthesized and its enantiomeric recognition properties were examined towards the enantiomers of tetrabutylammonium salts of chiral alpha-hydroxy and N-protected alpha-amino acids using UV-vis spectroscopy. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2012.11.020

文献信息

• Enantioselective C−H Olefination of α-Hydroxy and α-Amino Phenylacetic Acids by Kinetic Resolution
  作者：Kai-Jiong Xiao、Ling Chu、Jin-Quan Yu

  DOI：10.1002/anie.201510808

  日期：2016.2.18

  development of enantioselective C−H activation reactions by desymmetrization. However, the requirement for the presence of two chemically identical prochiral C−H bonds represents an inherent limitation in scope. Reported is the first example of kinetic resolution by a palladium(II)‐catalyzed enantioselective C−H activation and C−C bond formation, thus significantly expanding the scope of enantioselective C−H

  在过去的十年中，关于通过去对称化发展对映选择性CH活化反应的研究取得了重大进展。但是，要求存在两个化学上相同的前手性CH键代表了范围上的固有限制。报道的第一个通过钯（II）催化对映选择性CH活化和CC键形成动力学拆分的例子，从而显着扩大了对映选择性CH活化反应的范围。
• Sulfonamides
  申请人：Crosignani Stefano

  公开号：US20110028509A1

  公开（公告）日：2011-02-03

  The invention relates to compounds of formula I wherein R 1 , R 2 , R 4 , R a , R b , R c , R e , A*, W 1 , W 2 and W 3 are as defined in claim 16 , for the treatment of CXCR3 related diseases.

  该发明涉及式I的化合物，其中R1、R2、R4、Ra、Rb、Rc、Re、A*、W1、W2和W3的定义如权利要求16所述，用于治疗与CXCR3相关的疾病。