4-((tert-butoxycarbonyl)amino)heptanedioic acid | 848242-88-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-((tert-butoxycarbonyl)amino)heptanedioic acid
• 英文别名: 4-(N-Boc-amino)-1,6-heptanedioic acid；4-[(2-methylpropan-2-yl)oxycarbonylamino]heptanedioic acid
• CAS: 848242-88-6
• 化学式: C₁₂H₂₁NO₆
• 分子量: 275.302
• InChiKey: CVMSTDAWIAVWJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  19
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-((tert-butoxycarbonyl)amino)heptanedioic acid 在 palladium on activated charcoal 氢气 、 三乙胺 、 N,N'-羰基二咪唑 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 20.0 ℃ 、111.46 kPa 条件下， 反应 10.0h， 生成 1,3,5-benztri-(4-pimel-N,N'-dihydroxylamide)amide
  参考文献：
  名称：

  Branched Coordination Multilayers on Gold

  摘要：

  AC(3)-symmetric tridentate hexahydroxamate ligand molecule was specially synthesized and used for coordination self-assembly of branched multilayers on Au surfaces precoated with a self-assembled monolayer (SAM) of ligand anchors. Layer-by-layer (LbL) growth of multilayers via metal-organic coordination using Zr4+ ions proceeds with high regularity, adding one molecular layer in each step, as shown by ellipsometry, wettability, UV-vis spectroscopy, and atomic force microscopy (AFM). The branched multilayer films display improved stiffness, as well as a unique defect self-repair capability, attributed to cross-linking in the layers and lateral expansion over defects during multilayer growth. Transmetalation, i.e., exposure of Zr4+-based assemblies to Hf4+ ions, was used to evaluate the cross-linking. Conductive atomic force microscopy (AFM) was used to probe the electrical properties of the multilayers, revealing excellent dielectric behavior. The special properties of the branched layers were emphasized by comparison with analogous multilayers prepared similarly using linear (tetrahydroxamate) ligand molecules. The process of defect annihilation by bridging over defective areas, attributed to lateral expansion via the excess bishydroxamate groups, was demonstrated by introduction of artificial defects in the anchor monolayer, followed by assembly of two layers of either the linear or the branched molecule. Analysis of selective binding of Au nanoparticles (NIPS) to unblocked defects emphasized the superior repair mechanism in the branched layers with respect to the linear ones.

  DOI：

  10.1021/ja0556676
• 作为产物：
  描述：

  4-酮庚二酸 在 sodium hydroxide 、 氯化亚砜 、 sodium cyanoborohydride 、 氯化铵 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 51.0h， 生成 4-((tert-butoxycarbonyl)amino)heptanedioic acid
  参考文献：
  名称：

  Branched Coordination Multilayers on Gold

  摘要：

  AC(3)-symmetric tridentate hexahydroxamate ligand molecule was specially synthesized and used for coordination self-assembly of branched multilayers on Au surfaces precoated with a self-assembled monolayer (SAM) of ligand anchors. Layer-by-layer (LbL) growth of multilayers via metal-organic coordination using Zr4+ ions proceeds with high regularity, adding one molecular layer in each step, as shown by ellipsometry, wettability, UV-vis spectroscopy, and atomic force microscopy (AFM). The branched multilayer films display improved stiffness, as well as a unique defect self-repair capability, attributed to cross-linking in the layers and lateral expansion over defects during multilayer growth. Transmetalation, i.e., exposure of Zr4+-based assemblies to Hf4+ ions, was used to evaluate the cross-linking. Conductive atomic force microscopy (AFM) was used to probe the electrical properties of the multilayers, revealing excellent dielectric behavior. The special properties of the branched layers were emphasized by comparison with analogous multilayers prepared similarly using linear (tetrahydroxamate) ligand molecules. The process of defect annihilation by bridging over defective areas, attributed to lateral expansion via the excess bishydroxamate groups, was demonstrated by introduction of artificial defects in the anchor monolayer, followed by assembly of two layers of either the linear or the branched molecule. Analysis of selective binding of Au nanoparticles (NIPS) to unblocked defects emphasized the superior repair mechanism in the branched layers with respect to the linear ones.

  DOI：

  10.1021/ja0556676

文献信息

• [EN] INSULIN RECEPTOR PARTIAL AGONISTS AND GLP-1 ANALOGUES<br/>[FR] AGONISTES PARTIELS DU RÉCEPTEUR DE L'INSULINE ET ANALOGUES DU GLP-1
  申请人：MERCK SHARP & DOHME

  公开号：WO2017205191A1

  公开（公告）日：2017-11-30

  The present invention provides compositions comprising insulin receptor partial agonists in association with GLP-1 analogues (e.g., liraglutide) as well as methods for using the compositions for example, to treat or prevent diabetes or to decrease body weight.

  本发明提供了包含胰岛素受体部分激动剂与GLP-1类似物（例如利拉鲁肽）的组合物，以及使用该组合物的方法，例如用于治疗或预防糖尿病或减轻体重。
• ELECTROCHEMICAL AFFINITY BIOSENSOR SYSTEM AND METHODS
  申请人：DIEBOLD Eric R.

  公开号：US20120125788A1

  公开（公告）日：2012-05-24

  The present invention provides novel osmium-based electrochemical species for the detection of wide variety of analytes using immunological techniques. The present invention also provides diagnostic kits and test sensors supporting electrode structures that can be used with the osmium-based electrochemical species. The test sensor can be fabricated to support interdigitated arrays of electrodes that have been designed to provide amplification of the electrical signal amplification desired to analyze analytes that may be present at low concentrations.

  本发明提供了一种新型的以锇为基础的电化学物种，可利用免疫学技术检测各种分析物。本发明还提供了诊断试剂盒和测试传感器支持电极结构，可与基于锇的电化学物种一起使用。测试传感器可制造成支持交错电极阵列的形式，这些电极已被设计为提供所需的电信号放大，以分析可能存在低浓度的分析物。
• [EN] BICYCLIC PEPTIDE LIGAND DRUG CONJUGATES<br/>[FR] CONJUGUÉS DE MÉDICAMENT À LIGAND PEPTIDIQUE BICYCLIQUE
  申请人：BICYCLERD LTD

  公开号：WO2022079445A1

  公开（公告）日：2022-04-21

  The present invention relates to drug conjugates comprising at least two polypeptides which are each covalently bound to aromatic molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. The invention also relates to pharmaceutical compositions comprising said drug conjugates and to the use of said drug conjugates in preventing, suppressing or treating diseases, such as those which may be alleviated by cell death, in particular diseases characterised by defective cell types, proliferative disorders such as cancer and autoimmune disorders such as rheumatoid arthritis.

  本发明涉及药物偶联物，其包含至少两个多肽，每个多肽都与芳香分子支架共价结合，从而在支架的连接点之间形成两个或更多的多肽环。本发明还涉及包括所述药物偶联物的制药组合物以及使用所述药物偶联物预防、抑制或治疗疾病，特别是由缺陷细胞类型、增殖性疾病（如癌症）和自身免疫性疾病（如类风湿性关节炎）所表征的疾病。
• Mononuclear osmium complexes for use in biosensors
  申请人：Roche Diagnostics GmbH

  公开号：EP2465862A1

  公开（公告）日：2012-06-20

  The present invention provides novel osmium-based electrochemical species of formula IV for the detection of wide variety of analytes using immunological techniques. Also provided are precursor complexes thereof and a method for detecting an analyte in a liquid sample involving the use of a complex IV.

  本发明提供了新型的式 IV 锇基电化学物质，用于利用免疫学技术检测多种分析物。 本发明还提供了其前体络合物以及使用络合物 IV 检测液体样品中分析物的方法。
• Insulin receptor partial agonists
  申请人：MERCK SHARP & DOHME CORP.

  公开号：US10017556B2

  公开（公告）日：2018-07-10

  Insulin dimers and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed.

  本研究公开了可作为胰岛素受体部分激动剂的胰岛素二聚体和胰岛素类似物二聚体。