3-Acetyl-2-methoxypyrazolo<1,5-a>-pyridin | 55908-48-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: 3-Acetyl-2-methoxypyrazolo<1,5-a>-pyridin
• 英文别名: 1-(2-methoxy-pyrazolo[1,5-a]pyridin-3-yl)-ethanone；3-acetyl-2-methoxypyrazolo[1,5-a]pyridine；1-(2-methoxypyrazolo[1,5-a]pyridin-3-yl)ethanone
• CAS: 55908-48-0
• 化学式: C₁₀H₁₀N₂O₂
• 分子量: 190.202
• InChiKey: IXEFVRPLVBIOIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  43.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-Acetyl-2-hydroxypyrazolo<1,5-a>pyridin 、 碘甲烷 以35%的产率得到
  参考文献：
  名称：

  KATO T.; MASUDA S., CHEM. AND PHARM. BULL. , 1975, 23, NO 2, 452-455

  摘要：

  DOI：

文献信息

• Novel pyrazolo [1,5-a]pyridines
  申请人：Kyorin Pharmaceutical Co., Ltd.

  公开号：US04028370A1

  公开（公告）日：1977-06-07

  The present invention provides substituted pyrazolo[1,5-a]pyridine derivatives expressed by a compound of the general formula (I), ##STR1## (wherein: X is hydrogen atom or methyl group; R is hydrogen atom, straight or branched lower alkyl group, lower alkoxy group, lower alkylthio group, dialkylamino group, alkyleneimino group, and morpholino group; R.sub.1 is different from R and is hydrogen atom, straight or branched lower alkyl group, lower alkoxy alkyl group, and dialkylamino group). The compound of the present invention can be prepared by reacting a compound of the general formula (II), ##STR2## in which X and R are as shown hereinbefore, with a compound of the general formula (III), in which R.sub.1 is as shown hereinbefore, R.sub.1 COOH (III) or with a functional derivative of the compound of the general formula (III).

  本发明提供了一种由通式(I)化合物表达的取代的吡唑并[1,5-a]吡啶衍生物，其中：X是氢原子或甲基基团；R是氢原子、直链或支链低级烷基基团、低级烷氧基基团、低级烷基硫基基团、二烷基氨基基团、烷基亚氨基基团和吗啉基团；R1与R不同，是氢原子、直链或支链低级烷基基团、低级烷氧基烷基基团和二烷基氨基基团。本发明的化合物可以通过将通式(II)化合物（其中X和R如上所述）与通式(III)化合物反应而制备得到，其中R1如上所述，R1 COOH(III)或通式(III)化合物的功能衍生物。
• Pyrazolo\x9b1,5-a!pyridines \n'
  申请人：Kyorin Pharmaceutical Co., Ltd.

  公开号：US04097483A1

  公开（公告）日：1978-06-27

  The present invention provides substituted pyrazolo\x9b1,5-a!pyridine \n' derivatives expressed by a compound of the general formula (I), ##STR1## (wherein: X is hydrogen atom or methyl group; R is hydrogen atom, straight or branched lower alkyl group, lower alkoxy group, lower alkylthio group, dialkylamino group, alkyleneimino group, and morpholino group; R.sub.1 is different from R and is hydrogen atom, straight or branched lower alkyl group, lower alkoxy alkyl group, and dialkylamino group). The compound of the present invention can be prepared by reacting a compound of the general formula (II), ##STR2## in which X and R are as shown hereinbefore, with a compound of the general formula (III), in which R.sub.1 is as shown hereinbefore, R.sub.1 COOH (III) or with a functional derivative of the compound of the general formula (III).

  本发明提供了由通式（I）的化合物表达的取代的吡唑并[1,5-a]吡啶衍生物，其中：X为氢原子或甲基基团；R为氢原子、直链或支链低级烷基基团、低级烷氧基基团、低级烷基硫基团、二烷基氨基基团、烷基亚氨基基团和吗啉基团；R1与R不同，为氢原子、直链或支链低级烷基基团、低级烷氧基烷基基团和二烷基氨基基团。本发明的化合物可通过将通式（II）的化合物与通式（III）的化合物反应制备而成，其中X和R如上所示，R1如上所示，R1为COOH或通式（III）的官能衍生物。
• US4028370A
  申请人：——

  公开号：US4028370A

  公开（公告）日：1977-06-07
• KATO T.; MASUDA S., CHEM. AND PHARM. BULL. <CPBT-AL>, 1975, 23, NO 2, 452-455
  作者：KATO T.、 MASUDA S.

  DOI：——

  日期：——