3-(4-fluorophenyl)-3-[4-(1H-imidazol-1-yl)phenyl]prop-2-en-1-one | 1198467-69-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 3-(4-fluorophenyl)-3-[4-(1H-imidazol-1-yl)phenyl]prop-2-en-1-one
• 英文别名: (E)-1-(4-fluorophenyl)-3-(4-imidazol-1-ylphenyl)prop-2-en-1-one
• CAS: 1198467-69-4
• 化学式: C₁₈H₁₃FN₂O
• 分子量: 292.312
• InChiKey: FKKWRIBTOADEII-XCVCLJGOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  34.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-氟苯乙酮 、 1-(4-甲醛基苯基)咪唑 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 以72%的产率得到3-(4-fluorophenyl)-3-[4-(1H-imidazol-1-yl)phenyl]prop-2-en-1-one
  参考文献：
  名称：

  Anti-oxidant, anti-fungal and anti-leishmanial activities of novel 3-[4-(1H-imidazol-1-yl) phenyl]prop-2-en-1-ones

  摘要：

  A series of new 3-[4-(1H-imidazol-1-yl) phenyl]prop-2-en-1-ones were synthesized by the condensation of various acetophenones with 4-(1H-imidazol-1-yl) benzaldehyde which was itself prepared by the N-arylation of imidazole using hexadecyltrimethylammonium bromide as catalyst for the first time. All the synthesized compounds were subjected to preliminary evaluation for their anti-leishmanial, anti-oxidant and anti-fungal activities. Few of the synthesized compounds showed significant activities. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.06.038

文献信息

• Anti-oxidant, anti-fungal and anti-leishmanial activities of novel 3-[4-(1H-imidazol-1-yl) phenyl]prop-2-en-1-ones
  作者：Tanvir Hussain、Hamid Latif Siddiqui、Muhammad Zia-ur-Rehman、Muhammad Masoom Yasinzai、Masood Parvez

  DOI：10.1016/j.ejmech.2009.06.038

  日期：2009.11

  A series of new 3-[4-(1H-imidazol-1-yl) phenyl]prop-2-en-1-ones were synthesized by the condensation of various acetophenones with 4-(1H-imidazol-1-yl) benzaldehyde which was itself prepared by the N-arylation of imidazole using hexadecyltrimethylammonium bromide as catalyst for the first time. All the synthesized compounds were subjected to preliminary evaluation for their anti-leishmanial, anti-oxidant and anti-fungal activities. Few of the synthesized compounds showed significant activities. (C) 2009 Elsevier Masson SAS. All rights reserved.