2-(3,5-di-tert-butyl-4-hydroxybenzylidene)indan-1-one | 137506-95-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 2-(3,5-di-tert-butyl-4-hydroxybenzylidene)indan-1-one
• 英文别名: (E)-2-(3,5-Di-tert-butyl-4-hydroxybenzylidene)indan-1-one；(2E)-2-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]-3H-inden-1-one
• CAS: 137506-95-7
• 化学式: C₂₄H₂₈O₂
• 分子量: 348.485
• InChiKey: SMPSMMSABMAUMB-GZTJUZNOSA-N

物化性质

• 沸点：
  467.1±45.0 °C(Predicted)
• 密度：
  1.107±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-茚酮 、 3,5-二叔丁基-4-羟基苯甲醛 在 硫酸 作用下， 以 溶剂黄146 为溶剂， 反应 51.0h， 以69%的产率得到2-(3,5-di-tert-butyl-4-hydroxybenzylidene)indan-1-one
  参考文献：
  名称：

  Synthèse et activité anti-inflammatoire de (3,5-di-tert-butyl-4-hydroxybenzylidène) cyclanones et composés apparentés

  摘要：

  Some (3,5-di-tert-butyl-4-hydroxybenzylidene) cyclanones were synthesized and evaluated for anti-inflammatory activity in carragenin-induced rat paw edema assay. These compounds are slightly less active than phenylbutazone. Their inhibitory effects in vitro on human platelet aggregation have been also examined. The present study shows that the inhibitor profile of the tested compounds on platelet aggregation induced by arachidonic acid (AA), collagen and adenosine diphosphate (ADP) bears similarly to that of acetylsalicylic acid. The free radical scavenging activity against 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical was measured by Electron Spin Resonance spectrometry. All the studied compounds scavenge the DPPH radical, dose dependently.

  DOI：

  10.1016/0223-5234(91)90152-d