meso-(N,N-dimethylamido)dipyrromethane | 248914-89-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: meso-(N,N-dimethylamido)dipyrromethane
• 英文别名: N,N-dimethyl-2,2-bis(1H-pyrrol-2-yl)acetamide
• CAS: 248914-89-8
• 化学式: C₁₂H₁₅N₃O
• 分子量: 217.271
• InChiKey: PKSXKSLXOZUBER-UHFFFAOYSA-N

物化性质

• 沸点：
  462.0±45.0 °C(Predicted)
• 密度：
  1.206±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  51.9
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  乙醛酸甲酯 、 meso-(N,N-dimethylamido)dipyrromethane 在 三氟化硼乙醚 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以1.7%的产率得到
  参考文献：
  名称：

  Superoxide dismutase mimetics. Part 2: synthesis and structure–Activity relationship of glyoxylate- and glyoxamide-Derived metalloporphyrins

  摘要：

  Novel glyoxylate- and glyoxamide-derived metalloporphyrins 26-58 were synthesized and evaluated as potential superoxide dismutase (SOD) mimetics. Relative to previously studied MnTBAP analogues, the glyoxylate-derived metalloporphyrins 32, 39, and 54 and glyoxamide-derived metalloporphyrin 49, exhibited enhanced activity in the SOD assay and the majority of the analogues in the current series showed enhanced inhibition of lipid peroxidation and catalase activity. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(03)00272-4
• 作为产物：
  描述：

  吡咯 、 N、N-二甲基-2-氧代乙酰胺 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 以31%的产率得到meso-(N,N-dimethylamido)dipyrromethane
  参考文献：
  名称：

  Superoxide dismutase mimetics. Part 2: synthesis and structure–Activity relationship of glyoxylate- and glyoxamide-Derived metalloporphyrins

  摘要：

  Novel glyoxylate- and glyoxamide-derived metalloporphyrins 26-58 were synthesized and evaluated as potential superoxide dismutase (SOD) mimetics. Relative to previously studied MnTBAP analogues, the glyoxylate-derived metalloporphyrins 32, 39, and 54 and glyoxamide-derived metalloporphyrin 49, exhibited enhanced activity in the SOD assay and the majority of the analogues in the current series showed enhanced inhibition of lipid peroxidation and catalase activity. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(03)00272-4

文献信息

• Superoxide dismutase mimetics. Part 2: synthesis and structure–Activity relationship of glyoxylate- and glyoxamide-Derived metalloporphyrins
  作者：Michael P Trova、Polivina Jolicia F Gauuan、Anthony D Pechulis、Stephen M Bubb、Stephen B Bocckino、James D Crapo、Brian J Day

  DOI：10.1016/s0968-0896(03)00272-4

  日期：2003.7

  Novel glyoxylate- and glyoxamide-derived metalloporphyrins 26-58 were synthesized and evaluated as potential superoxide dismutase (SOD) mimetics. Relative to previously studied MnTBAP analogues, the glyoxylate-derived metalloporphyrins 32, 39, and 54 and glyoxamide-derived metalloporphyrin 49, exhibited enhanced activity in the SOD assay and the majority of the analogues in the current series showed enhanced inhibition of lipid peroxidation and catalase activity. (C) 2003 Elsevier Science Ltd. All rights reserved.