(2R)-2-methyl-3-phenylmethoxypropanamide | 510730-60-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R)-2-methyl-3-phenylmethoxypropanamide
• CAS: 510730-60-6
• 化学式: C₁₁H₁₅NO₂
• 分子量: 193.246
• InChiKey: SXFRVNMNEJROGR-SECBINFHSA-N

物化性质

• 沸点：
  358.4±25.0 °C(Predicted)
• 密度：
  1.077±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2R)-2-methyl-3-phenylmethoxypropanamide 在 三乙胺 、 [双(三氟乙酰氧基)碘]苯 作用下， 以 水 、 乙腈 为溶剂， 反应 3.5h， 生成 (R)-1-benzyloxy-N-tert-butoxycarbonyl-2-propylamine
  参考文献：
  名称：

  Synthesis of chiral α-amino acids

  摘要：

  A novel method for the synthesis of chiral alpha-amino acids has been developed where the acid functionality was constructed by oxidizing a hydroxymethyl group introduced by Evans' method in the alpha-position of an appropriate acid substrate and the amino part came from the amide of the original carboxyl group following a modified Hofmann rearrangement reaction. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(02)02433-4
• 作为产物：
  描述：

  (-)-(R)-3-benzyloxy-2-methylpropionic acid 在 ammonium hydroxide 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 (2R)-2-methyl-3-phenylmethoxypropanamide
  参考文献：
  名称：

  Synthesis of chiral α-amino acids

  摘要：

  A novel method for the synthesis of chiral alpha-amino acids has been developed where the acid functionality was constructed by oxidizing a hydroxymethyl group introduced by Evans' method in the alpha-position of an appropriate acid substrate and the amino part came from the amide of the original carboxyl group following a modified Hofmann rearrangement reaction. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(02)02433-4

文献信息

• BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS
  申请人：PORTOLA PHARMACEUTICALS, INC.

  公开号：US20150038492A1

  公开（公告）日：2015-02-05

  The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as Non Hodgkin's Lymphoma.

  本发明涉及式I化合物及其药学上可接受的盐、酯和前药，其是Syk激酶抑制剂。本发明还涉及制备这种化合物所使用的中间体，制备这种化合物的方法，含有这种化合物的制药组合物，抑制Syk激酶活性的方法，抑制血小板聚集的方法，以及预防或治疗至少部分由Syk激酶活性介导的多种疾病的方法，例如非霍奇金淋巴瘤。
• US9359375B2
  申请人：——

  公开号：US9359375B2

  公开（公告）日：2016-06-07
• Synthesis of chiral α-amino acids
  作者：Tushar K Chakraborty、Animesh Ghosh

  DOI：10.1016/s0040-4039(02)02433-4

  日期：2002.12

  A novel method for the synthesis of chiral alpha-amino acids has been developed where the acid functionality was constructed by oxidizing a hydroxymethyl group introduced by Evans' method in the alpha-position of an appropriate acid substrate and the amino part came from the amide of the original carboxyl group following a modified Hofmann rearrangement reaction. (C) 2002 Published by Elsevier Science Ltd.