3-(2-羧基-环己基)-丙酸 | 103263-24-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 3-(2-羧基-环己基)-丙酸
• 英文名称: 3-(2-carboxy-cyclohexyl)-propionic acid
• 英文别名: β-(2-Carboxy-cyclohexyl)-propionsaeure；3-(2-Carboxy-cyclohexyl)-propionsaeure；Cyclohexan-carbonsaeure-(1)-(β-propionsaeure)-(2)；2-Carboxy-oktahydrozimtsaeure；2-(2-Carboxyethyl)cyclohexane-1-carboxylic acid
• CAS: 103263-24-7
• 化学式: C₁₀H₁₆O₄
• 分子量: 200.235
• InChiKey: OSYCDUDSGQZZMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(2-羧基-环己基)-丙酸 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Windaus; Hueckel; Reverey, Chemische Berichte, 1923, vol. 56, p. 93

  摘要：

  DOI：
• 作为产物：
  描述：

  3-(2-羧基苯基)丙酸 在 溶剂黄146 、 铂 作用下， 生成 3-(2-羧基-环己基)-丙酸
  参考文献：
  名称：

  Windaus; Hueckel; Reverey, Chemische Berichte, 1923, vol. 56, p. 93

  摘要：

  DOI：

文献信息

• ENANTIOSELECTIVE BIOCATALYTIC PREPARATION OF 4-CYANO-SUBSTITUTED 1-AMINOINDANE AND OZANIMOD
  申请人：Universität Bielefeld

  公开号：EP3553179A1

  公开（公告）日：2019-10-16

  The present invention is directed to a process for the enantioselective biocatalytic preparation of 4-substituted 1-aminoindanes of general formula and a process for the preparation of Ozanimod, preferably involving the enantioselective biocatalytic process of preparing 4-substituted 1-aminoindanes of the above general formula, wherein R = -CN and Y = H.

  本发明涉及一种手性选择性生物催化制备通式为4-取代基-1-氨基茚烷的过程，以及一种制备Ozanimod的过程，优选涉及上述通式中R = -CN和Y = H的4-取代基-1-氨基茚烷的手性选择性生物催化制备过程。
• The use of L-Arginine in the treatment of hypertension and other vascular disorders
  申请人：Levere, Richard D.

  公开号：EP0441119A2

  公开（公告）日：1991-08-14

  A method for treating a high vascular resistance disorder in a mammal by administering to a mammalian organism in need of such treatment a sufficient amount of L-arginine or pharmaceutically acceptable salt thereof to treat a high vascular resistance disorder. The L-arginine is typically administered in the range of about 1 mg to 1500 mg per day. High vascular resistance disorders include hypertension, primary or secondary vasospasm, angina pectoris, cerebral ischemia and preeclampsia. Also disclosed is a method for preventing or treating bronchial asthma in a mammal by administering to a mammalian organism in need of such prevention or treatment a sufficient amount of L-arginine to prevent or treat bronchial asthma.

  一种治疗哺乳动物高血管阻力症的方法，向需要治疗的哺乳动物机体施用足量的L-精氨酸或其药学上可接受的盐以治疗高血管阻力症。L-精氨酸的用量通常为每天约1毫克至1500毫克。高血管阻力疾病包括高血压、原发性或继发性血管痉挛、心绞痛、脑缺血和先兆子痫。还公开了一种用于预防或治疗哺乳动物支气管哮喘的方法，该方法是向需要预防或治疗支气管哮喘的哺乳动物机体施用足量的 L-精氨酸以预防或治疗支气管哮喘。
• COMPOSITION COMPRISING L-ARGININE AS A MUSCLE GROWTH STIMULANT AND USE THEREOF
  申请人：——

  公开号：US20030119888A1

  公开（公告）日：2003-06-26

  A composition for stimulating muscle growth, comprising an effective amount of L-arginine or a salt thereof, a pH control agent for controlling the pH at less than 7 and a pharmaceutically acceptable carrier. A method of using the composition to achieve muscle growth or an immune response is also described.

  一种刺激肌肉生长的组合物，包含有效量的 L-精氨酸或其盐、用于将 pH 值控制在 7 以下的 pH 值控制剂和药学上可接受的载体。还描述了使用该组合物实现肌肉生长或免疫反应的方法。
• Composition comprising L-arginine as a muscle growth stimulant and use thereof
  申请人：Allen de Wees Ann

  公开号：US20050043287A1

  公开（公告）日：2005-02-24

  A composition for stimulating muscle growth, comprising an effective amount of L-arginine or a salt thereof, a pH control agent for controlling the pH at less than 7 and a pharmaceutically acceptable carrier. A method of using the composition to achieve muscle growth or an immune response is also described.

  一种刺激肌肉生长的组合物，包含有效量的 L-精氨酸或其盐、用于将 pH 值控制在 7 以下的 pH 值控制剂和药学上可接受的载体。还描述了使用该组合物实现肌肉生长或免疫反应的方法。
• Methods of treating various conditions by administration of sustained released L-Arginine
  申请人：Ron S. Eyal

  公开号：US20050288372A1

  公开（公告）日：2005-12-29

  The present invention provides methods for using L-arginine formulations, such as sustained release formulations, for various indications, including lowering triglyceride levels, inducing thermogenesis, weight loss and treatment and prevention of obesity and obesity related conditions, such as diabetes. Moreover, the present invention provides methods for treating or preventing other indications, such as asthma.

  本发明提供了将 L-精氨酸制剂（如缓释制剂）用于各种适应症的方法，包括降低甘油三酯水平、诱导产热、减肥以及治疗和预防肥胖和肥胖相关疾病（如糖尿病）。此外，本发明还提供了治疗或预防哮喘等其他适应症的方法。