3-(2-羧基-环己基)-丙酸

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 3-(2-羧基-环己基)-丙酸
• 英文名称: (1R*,2S*)-2-(2-carboxyethyl)cyclohexane-1-carboxylic acid
• 英文别名: (+/-)-3-(trans-2-Carboxy-cyclohexyl)-propionsaeure；(+/-)-3-(trans-2-carboxy-cyclohexyl)-propionic acid；(1S,2R)-2-(2-carboxyethyl)cyclohexane-1-carboxylic acid
• 化学式: C₁₀H₁₆O₄
• 分子量: 200.235
• InChiKey: OSYCDUDSGQZZMX-SFYZADRCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.74
• 重原子数：
  14.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  74.6
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  3-(2-羧基-环己基)-丙酸 在 硫酸 作用下， 生成 ethyl (1R,2S)-2-(3-ethoxy-3-oxopropyl)cyclohexane-1-carboxylate
  参考文献：
  名称：

  Hueckel et al., Justus Liebigs Annalen der Chemie, 1935, vol. 518, p. 155,173, 175

  摘要：

  DOI：
• 作为产物：
  描述：

  3-(2-羧基苯基)丙酸 生成 3-(2-羧基-环己基)-丙酸
  参考文献：
  名称：

  The Chemical Constituents of Himantandra (Galbulimima) Species. IV. The Structures of Himbacine, Himbeline, Himandravine, and Himgravine

  摘要：

  通过一系列广泛的降解 通过一系列广泛的降解过程，包括脱氢、彻底甲基化和氧化，确定了 himbacine 的结构。 结构。它是一类新生物碱的首 生物碱。通过简单的转化，赫巴碱、赫桑德拉碱和赫格拉碱 的结构也已确定。 确立。

  DOI：

  10.1071/ch9610106

文献信息

• Catalyst-controlled site-selective methylene C–H lactonization of dicarboxylic acids
  作者：Hau Sun Sam Chan、Ji-Min Yang、Jin-Quan Yu

  DOI：10.1126/science.abq3048

  日期：2022.6.24

  and γ-methylene carbon-hydrogen (C-H) bonds of free carboxylic acids is a long-standing challenge. Here we show that, with a pair of palladium catalysts assembled with quinoline-pyridone ligands of different chelate ring sizes, it is possible to perform highly site-selective monolactonization reactions with a wide range of dicarboxylic acids, generating structurally diverse and synthetically useful γ-

  游离羧酸的β-和γ-亚甲基碳氢（CH）键的催化剂控制的位点选择性活化是一个长期存在的挑战。在这里，我们表明，通过一对由不同螯合环尺寸的喹啉-吡啶酮配体组装的钯催化剂，可以与多种二羧酸进行高度位点选择性的单内酯化反应，产生结构多样且合成上有用的γ-和δ-内酯通过位点选择性β-或γ-亚甲基CH活化。剩余的羧基可作为进一步合成应用的多功能关键，如从丰富的二羧酸中全合成两种天然产物 myrotheciumone A 和pedicellosine 所证明的那样。
• The Development of the Surgical Treatment of Morbid Obesity
  作者：Mervyn Deitel、Scott A. Shikora

  DOI：10.1080/07315724.2002.10719237

  日期：2002.10

  Morbid obesity is defined as obesity with a body mass index greater than or equal to40, or greater than or equal to35 with secondary serious diseases. Conservative medical therapies in these individuals generally fail to sustain weight loss. Thus, surgical operations have evolved which are based on gastric restriction and/or malabsorption. Historically, the intestinal bypass operation was followed by the gastric bypass operation (in some instances combined with intestinal bypass) or by the gastric restriction operations (gastroplasty or gastric banding), Laparoscopic techniques are now being used for these operations, but require surgical expertise in both the bariatric operations and advanced laparoscopic skills. All operations may have complications, but these occur in a very small percent. Postoperative follow-up and nutritional surveillance are mandatory. The operations result in significant weight loss, and the current operations have a mean lasting weight loss of about 50 percent of excess body weight, with improvement or resolution of most obesity-associated conditions. There is evidence that even modest to moderate weight loss in these individuals has significant medical benefit.
• Palladium(II)-catalyzed carboxylation reactions of olefins: scope and utility
  作者：J. K. Stille、R. Divakaruni

  DOI：10.1021/jo01334a006

  日期：1979.9
• Hueckel, Justus Liebigs Annalen der Chemie, 1938, vol. 533, p. 1,26
  作者：Hueckel

  DOI：——

  日期：——
• 435. Alicyclic glycols. Part XVII. The decalin-2 : 3-diols
  作者：Md. Erfan Ali、L. N. Owen

  DOI：10.1039/jr9580002119

  日期：——