Benzyl-acetylglycinat | 26210-43-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Benzyl-acetylglycinat
• 英文别名: N-acetyl-glycine benzyl ester；N-Acetyl-glycin-benzylester；N-[2-(Benzyloxy)-2-oxoethyl]ethanimidic acid；benzyl 2-acetamidoacetate
• CAS: 26210-43-5
• 化学式: C₁₁H₁₃NO₃
• mdl: MFCD24388005
• 分子量: 207.229
• InChiKey: PRQXYGWRFIWWFJ-UHFFFAOYSA-N

物化性质

• 熔点：
  50.8-51.6 °C
• 沸点：
  175-180 °C(Press: 1-1.2 Torr)
• 密度：
  1.143±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.272
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Benzyl-acetylglycinat 在 tetraphosphorus decasulfide 、 sodium carbonate 作用下， 以 四氢呋喃 为溶剂， 反应 2.5h， 以80%的产率得到Thioacetylamino-acetic acid benzyl ester
  参考文献：
  名称：

  Brillon, Denis, Synthetic Communications, 1990, vol. 20, # 19, p. 3085 - 3095

  摘要：

  DOI：
• 作为产物：
  描述：

  N-乙酰甘氨酸 、 苯甲醇 在 硫酸 、 甲苯 作用下， 生成 Benzyl-acetylglycinat
  参考文献：
  名称：

  Syntheses and Reactions of Acyclic N,N-Diacylglycines

  摘要：

  DOI：

  10.1021/ja01138a030

文献信息

• [1,2,4] Triazolo [1,5, a] pyrimidin-2-ylurea derivative and use thereof
  申请人：Masuda Akira

  公开号：US20070010515A1

  公开（公告）日：2007-01-11

  Novel [1,2,4]triazolo[1,5-a]pyrimidine derivative of the general formula (1): (1) its prodrug or a pharmaceutically acceptable salt thereof, which exhibits an antigen presentation inhibiting activity and is useful as a preventive and/or therapeutic agent for immunological rejection and/or graft versus host reaction in organ/bone marrow transplant, autoimmune disease, allergic disease and/or inflammatory disease and also useful as an anticancer drug or as an immunological tolerance inducer for transplanted organ/transplanted bone marrow.

  这是一种通式为(1)的[1,2,4]三唑并[1,5-a]嘧啶衍生物的小说，其中(1)是其前药或其药学上可接受的盐，具有抗原呈递抑制活性，可用作预防和/或治疗器官/骨髓移植、自身免疫性疾病、过敏性疾病和/或炎症性疾病的免疫排斥和/或移植物抗宿主反应的预防和/或治疗剂，同时也可用作抗癌药物或用于移植器官/移植骨髓的免疫耐受诱导剂。
• Bacterial transforming agent
  申请人：Levey Ernest Michael

  公开号：US20060040871A1

  公开（公告）日：2006-02-23

  A method of increasing the sensitivity of a bacterial strain to a cell-wall active antimicrobial agent, to which the bacterial strain or a progenitor strain from which the bacterial strain has evolved is sensitive is described. The method comprises the step of exposing said bacterial strain to a transforming agent having the following formula (1): where moieties R 1 , and R 2 are each independently selected from alkyl, alkyloxy, alkyloxycarbonyl, alkylcarbonyloxy, alkenyl, alkenyloxy, alkenyloxycarbonyl, alkenylcarbonyloxy, alkynyl, alkynyloxy: alkynyloxycarbonyl, alkynylcarbonyloxy, each of which may be substituted or unsubstituted, straight chain or branched or cyclic, aryl, aryloxy, aryloxycarbonyl, arylcarbonyloxy, each of which may be substituted or unsubstituted and cabamoyl, moiety R 3 is selected from alkyl, alkyloxy, alkylcarbonyloxy, alkenyl, alkenyloxy, alkenylcarbonyloxy, alkynyl, alkynyloxy, alkynylcarbonyloxy, each of which may be substituted o unsubstituted, straight chain or branched or cyclic, aryl, aryloxy, arylcarbonyloxy, each of which may be substituted or unsubstituted, and carboxyl other than R 1 , R 2 , and R 3 are not all H, and Y is selected from a natural amino acid side chain. The use of an agent having the above formula in the manufacture of a medicament for increasing the sensitivity of a bacterial strain infecting, colonising or being carried by a patient, to an cell-wall active antimicrobial agent is also disclosed.

  本发明描述了一种提高细菌菌株对细胞壁活性抗菌剂敏感性的方法，该细菌菌株或由其进化而来的原生菌株对细胞壁活性抗菌剂敏感。该方法包括将所述细菌菌株暴露于具有下式（1）的转化剂中的步骤： 其中分子 R 1 和 R 2 各自独立地选自烷基、烷氧基、烷氧羰基、烷基羰基氧基、烯基、烯氧基、烯氧基羰基、烯基羰基氧基、炔基、炔氧基：炔氧基羰基、炔基羰基氧基，其中每一个都可以是取代或未取代的、直链或支链或环状的，芳基、芳氧基、芳氧基羰基、芳基羰基氧基，其中每一个都可以是取代或未取代的，以及卡巴莫伊尔，分子 R 3 选自烷基、烷氧基、烷基羰基氧基、烯基、烯基氧基、烯基羰基氧基、炔基、炔氧基、炔基羰基氧基（其中每个都可以是取代的或未取代的、直链或支链或环状的）、芳基、芳氧基、芳基羰基氧基（其中每个都可以是取代的或未取代的）和除 R 1 以外的羧基 1 , R 2 和 R 3 Y 选自天然氨基酸侧链。此外，还公开了具有上式的制剂在制造药物中的用途，该药物可提高感染、定植或由患者携带的细菌菌株对细胞壁活性抗菌剂的敏感性。
• Pd-catalyzed enantioselective synthesis of quaternary α-amino acid derivatives using a phenylalanine-derived P-chirogenic diaminophosphine oxide
  作者：Tetsuhiro Nemoto、Teisuke Harada、Takayoshi Matsumoto、Yasumasa Hamada

  DOI：10.1016/j.tetlet.2007.07.020

  日期：2007.9

  A Pd-catalyzed enantio selective synthesis of quaternary alpha-amino acid derivatives using a phenylalanine-derived P-chirogenic diaminophosphine oxide is described. Asymmetric allylic substitution using acyclic beta-keto esters with a nitrogen functional group at the alpha-carbon as prochiral nucleophiles proceeded in the presence of 5 mol % of Pd catalyst, 10 mol % of chiral diaminophosphine oxide 1j, BSA, and appropriate additives, affording the corresponding quaternary alpha-amino acid derivatives in excellent yield and in up to 92% ee. (c) 2007 Elsevier Ltd. All rights reserved.
• Preparation of esters of amino acids and of peptides under mild conditions
  作者：A. A. Mazurov、S. V. Antonenko、S. A. Andronati

  DOI：10.1007/bf00574742

  日期：1986.3
• Mallikarjun Reddy; Moses Babu; Sudhakar, Pharmazie, 2006, vol. 61, # 12, p. 994 - 998
  作者：Mallikarjun Reddy、Moses Babu、Sudhakar、Sharma、Sudershan Reddy、Vyas

  DOI：——

  日期：——