Primlev | 330988-72-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: Primlev
• 英文别名: (4R,4aS,7aR,12bS)-4a-hydroxy-9-methoxy-3-methyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;N-(4-hydroxyphenyl)acetamide
• CAS: 330988-72-2
• 化学式: C26H30N2O6
• 分子量: 466.5
• InChiKey: RJEIGSKSSKIIHG-RKXJKUSZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  34
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  108
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• NOVEL ANTIOXIDANTS AND METHODS OF TREATMENT
  申请人：Weiner Carl P.

  公开号：US20090318454A1

  公开（公告）日：2009-12-24

  Formula 1 is an antioxidant compound, wherein R, R1, or D is an antioxidant substituent; R and D are each independently selected from hydrogen or groups containing cysteine, thiols, disulfides, amino acids, amines, amides, or carboxylic acids; when one of R or D is hydrogen, the other includes a thiol, disulfide, or carboxylic acid; A is CO, SO, SO 2 , or C═S; E is one or more ring groups which are aromatic, carbocyclic, and/or heterocyclic 5, 6 and 7 membered rings being mono, bi, tri, tetra, penta, hexa, hepta or octa cyclic fused rings that are substituted or unsubstituted, each heterocyclic ring can include hetero atoms chosen from to O, S, N, Se, or P; each R1 is at a para, meta, and/or ortho position; n is 1, 2, 3, 4, or 5 for each ring; and each R1 is hydrogen or an antioxidant substituent.

  Formula 1是一种抗氧化化合物，其中R，R1或D是抗氧化剂取代基；R和D分别独立选择自氢或含有半胱氨酸，巯基，二硫键，氨基酸，胺，酰胺或羧酸的基团；当R或D中的一个是氢时，另一个包括巯基，二硫键或羧酸；A是CO，SO，SO2或C═S；E是一个或多个芳香族，碳环或杂环的环基团，其中5, 6和7个成员环可以是单环，双环，三环，四环，五环，六环，七环或八环的融合环，可以是取代或未取代的，每个杂环可以包含从O，S，N，Se或P选择的杂原子；每个R1位于对位，间位和/或邻位；n对于每个环是1, 2, 3, 4或5；每个R1是氢或抗氧化剂取代基。
• Opiate analogs selective for the delta -opioid receptor
  申请人：The Curators of the University of Missouri

  公开号：US20040122230A1

  公开（公告）日：2004-06-24

  Novel compounds which selectively bind to the &dgr;-opioid receptor have been designed. These compounds have greater selectivity, improved water (blood) solubility, and enhanced therapeutic value as analgesics. Because agonists with selectivity for the &dgr;-opioid receptor have shown promise in providing enhanced analgesis without the addictive properties, the compounds of the present invention are better than morphine, naltrindole (NTI), spiroindanyloxymorphone (SIOM), and other known &mgr;-opioid receptor selectors as analgesics.

  我们设计出了能选择性结合阿片受体的新型化合物。这些化合物具有更高的选择性、更好的水（血液）溶解性以及更高的镇痛治疗价值。由于对&dgr;-阿片受体具有选择性的激动剂有望提供更强的镇痛效果，但不会成瘾，因此本发明的化合物作为镇痛剂优于吗啡、纳尔吲哚（NTI）、螺茚氧吗啡酮（SIOM）和其他已知的&mgr;-阿片受体选择剂。
• N-ACETYLCYSTEINE COMPOSITIONS AND METHODS FOR THE TREATMENT AND PREVENTION OF DRUG TOXICITY
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：EP1379232B1

  公开（公告）日：2015-07-29
• EP1379232A4
  申请人：——

  公开号：EP1379232A4

  公开（公告）日：2008-04-23
• SILK RESERVOIRS FOR DRUG DELIVERY
  申请人：Trustees of Tufts College

  公开号：EP2827884A1

  公开（公告）日：2015-01-28