ethyl 3-<4-(hydroxymethyl)phenyl>pyridine-2-carboxylate | 164460-31-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: ethyl 3-<4-(hydroxymethyl)phenyl>pyridine-2-carboxylate
• 英文别名: Ethyl 3-[4-(hydroxymethyl)phenyl]pyridine-2-carboxylate
• CAS: 164460-31-5
• 化学式: C₁₅H₁₅NO₃
• 分子量: 257.289
• InChiKey: NZNJTOGMFNDJAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  59.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 3-<4-(hydroxymethyl)phenyl>pyridine-2-carboxylate 在 盐酸 、 氯化亚砜 、 sodium hydride 作用下， 反应 17.0h， 生成 2-butyl-4-chloro-5-(hydroxymethyl)-1-<<1-<2-(ethoxycarbonyl)pyridin-3-yl>-4-phenyl>methyl>-1H-imidazole
  参考文献：
  名称：

  Nonpeptide Angiotensin II Receptor Antagonists. Synthesis, in vitro Activity, and Molecular Modeling Studies of N-[(Heterobiaryl)methyl]imidazoles

  摘要：

  With the aim of explaining the influence of the structural changes on the biphenylic moiety on the activity, a series of N-[(heterobiaryl)methyl]imidazoles (I), constructed on the model of DuPont compounds by replacing either the central or terminal phenyl ring with a heteroaromatic one, such as furan, thiophene, thiazole, and pyridine, was synthesized. Compared to the reference DuPont compound (EXP-7711), all the heterobiaryl derivatives showed a reduced potency both in receptor binding (rat adrenal capsular membranes) and in the functional assay (angiotensin II-induced contraction of rabbit aorta strips). The lower activity was justified by the extensive molecular modeling studies, which took into consideration the conformational and electrostatic features of several heterobiaryl derivatives. On the basis of the results obtained, it was hypothesized that the central aromatic ring of the biarylic portion works as a spacer, orienting in the right way the terminal phenyl ring, whose electronic distribution is, instead, crucial to its fitting well with a lipophilic pocket at the receptor site.

  DOI：

  10.1021/jm00049a012
• 作为产物：
  描述：

  (4-(((四氢-2H-吡喃-2-基)氧基)甲基)苯基)硼酸 在 四(三苯基膦)钯 、 sodium carbonate 、 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 反应 0.5h， 生成 ethyl 3-<4-(hydroxymethyl)phenyl>pyridine-2-carboxylate
  参考文献：
  名称：

  Nonpeptide Angiotensin II Receptor Antagonists. Synthesis, in vitro Activity, and Molecular Modeling Studies of N-[(Heterobiaryl)methyl]imidazoles

  摘要：

  With the aim of explaining the influence of the structural changes on the biphenylic moiety on the activity, a series of N-[(heterobiaryl)methyl]imidazoles (I), constructed on the model of DuPont compounds by replacing either the central or terminal phenyl ring with a heteroaromatic one, such as furan, thiophene, thiazole, and pyridine, was synthesized. Compared to the reference DuPont compound (EXP-7711), all the heterobiaryl derivatives showed a reduced potency both in receptor binding (rat adrenal capsular membranes) and in the functional assay (angiotensin II-induced contraction of rabbit aorta strips). The lower activity was justified by the extensive molecular modeling studies, which took into consideration the conformational and electrostatic features of several heterobiaryl derivatives. On the basis of the results obtained, it was hypothesized that the central aromatic ring of the biarylic portion works as a spacer, orienting in the right way the terminal phenyl ring, whose electronic distribution is, instead, crucial to its fitting well with a lipophilic pocket at the receptor site.

  DOI：

  10.1021/jm00049a012

文献信息

• Anti-AIDS Agents. 15. Synthesis and Anti-HIV Activity of Dihydroseselins and Related Analogs
  作者：Li Huang、Yoshiki Kashiwada、L. Mark Cosentino、Sharon Fan、Chin-Ho Chen、Andrew T. McPhail、Toshihiro Fujioka、Kunihide Mihashi、Kuo-Hsiung Lee

  DOI：10.1021/jm00049a014

  日期：1994.11

  derivatives, seselin (3) and (+/-)-cis-(4), (+)-cis- (5), and (+/-)-trans-dihydroseselin-3',4'-diol (7) were also tested for their in vitro anti-HIV activity. An optically pure compound, 3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (16), showed potent inhibitory activity and remarkable selectivity against HIV replication. The EC50 value and in vitro therapeutic index (TI) of 16 are 4 x 10(-4) microM and

  为了评估其抗HIV活性，合成了42种基于Suksdorfin（1）结构的二氢香豆素。这些合成衍生物包括3'，4'-二-O-酰基-和3'-或4'-O-酰基-顺式-二氢芝麻素（8-21）和3'，4'-反式-二氢芝麻素与O-酰基和/或在3'和4'位置（6、22-43）的O-烷基。还制备了两个4'-叠氮基（44、45）和三个4'-烷基酰胺基（46、48、49）衍生物。通过使用光学纯试剂，合成了三对非对映异构体，并将其分离为光学纯化合物（14、15、16、17、38、39）。塞斯林（3）和（+/-）-顺-（4），（+）-顺-（5）和（+/-）-反-二氢塞塞林3'，4'与上述合成衍生物一起还测试了-二醇（7）的体外抗HIV活性。光学纯的化合物3'，4' -di-O-（-）-camphanoyl-（+）-cis-khellactone（16）具有较强的抑制活性，并且对HIV复制具有明显的选择性。EC50值和体外治疗指数（TI）为16分别为4
• Nonpeptide Angiotensin II Receptor Antagonists. Synthesis, in vitro Activity, and Molecular Modeling Studies of N-[(Heterobiaryl)methyl]imidazoles
  作者：Aldo Salimbeni、Renato Canevotti、Fabio Paleari、Fabrizio Bonaccorsi、Anna R. Renzetti、Laura Belvisi、Gianpaolo Bravi、Carlo Scolastico

  DOI：10.1021/jm00049a012

  日期：1994.11

  With the aim of explaining the influence of the structural changes on the biphenylic moiety on the activity, a series of N-[(heterobiaryl)methyl]imidazoles (I), constructed on the model of DuPont compounds by replacing either the central or terminal phenyl ring with a heteroaromatic one, such as furan, thiophene, thiazole, and pyridine, was synthesized. Compared to the reference DuPont compound (EXP-7711), all the heterobiaryl derivatives showed a reduced potency both in receptor binding (rat adrenal capsular membranes) and in the functional assay (angiotensin II-induced contraction of rabbit aorta strips). The lower activity was justified by the extensive molecular modeling studies, which took into consideration the conformational and electrostatic features of several heterobiaryl derivatives. On the basis of the results obtained, it was hypothesized that the central aromatic ring of the biarylic portion works as a spacer, orienting in the right way the terminal phenyl ring, whose electronic distribution is, instead, crucial to its fitting well with a lipophilic pocket at the receptor site.