N-(5-aminopentyl)-N-hydroxyacetamide | 144108-69-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(5-aminopentyl)-N-hydroxyacetamide
• 英文别名: N-acetyl-N-hydroxy-1,5-diaminopentane；N-hydroxy-acetyl-cadaverine；1-Amino-5--pentan
• CAS: 144108-69-0
• 化学式: C₇H₁₆N₂O₂
• mdl: MFCD20699310
• 分子量: 160.216
• InChiKey: ATUUAJPBSMFUFR-UHFFFAOYSA-N

物化性质

• 沸点：
  286.1±42.0 °C(Predicted)
• 密度：
  1.070±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  66.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(5-aminopentyl)-N-hydroxyacetamide 、 4-((5-aminopentyl)(hydroxy)amino)-4-oxobutanoic acid 在 DesD 作用下， 生成 去铁胺
  参考文献：
  名称：

  Engineering a cleavable disulfide bond into a natural product siderophore using precursor-directed biosynthesis

  摘要：

  在添加半胱氨酸的情况下，从链霉菌培养物中产生了一种含有二硫桥的细菌铁载体去铁胺B（DFOB）的类似物。

  DOI：

  10.1039/c8cc04981e
• 作为产物：
  描述：

  1-Carbobenzoxyamino-5-(N-acetyl-hydroxylamino)-pentan 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 生成 N-(5-aminopentyl)-N-hydroxyacetamide
  参考文献：
  名称：

  Stoffwechselprodukte von Actinomyceten。36. Mitteilung。黚死SYNTHESE DER铁草胺乙UND d 1

  摘要：

  天然微生物生长因子铁氧嘧啶B和D 1已通过反应顺序ⅢXI合成。

  DOI：

  10.1002/hlca.19620450228

文献信息

• Characterization of the promiscuous <i>N</i>-acyl CoA transferase, LgoC, in legonoxamine biosynthesis
  作者：Fleurdeliz Maglangit、Saad Alrashdi、Justine Renault、Laurent Trembleau、Catherine Victoria、Ming Him Tong、Shan Wang、Kwaku Kyeremeh、Hai Deng

  DOI：10.1039/d0ob00320d

  日期：——

  More than 500 siderophores are known to date, but only three were identified to be aryl-containing hydroxamate siderophores, legonoxamines A and B from Streptomyces sp. MA37, and aryl ferrioxamine 2 from Micrococcus luteus KLE1011.

  迄今已知超过500种铁载体，但只有三种被确认为含芳基羟酰胺的铁载体，分别是来自Streptomyces sp. MA37的legonoxamines A和B，以及来自Micrococcus luteus KLE1011的芳基铁螯合物2。
• [EN] ANTIBODY DRUG CONJUGATES<br/>[FR] CONJUGUÉS ANTICORPS-MÉDICAMENT
  申请人：HOFFMANN LA ROCHE

  公开号：WO2018095891A1

  公开（公告）日：2018-05-31

  The present invention pertains to an antibody-drug conjugate comprising an antibody, ferric iron and at least one drug molecule,and to a pharmaceutical composition comprising the antibody-drug conjugate. The invention further relates to the use of the antibody-drug conjugates in the treatment of diseases, e.g. cancer.

  本发明涉及一种抗体-药物结合物，其包括抗体、铁离子和至少一种药物分子，并涉及一种包括抗体-药物结合物的制药组合物。本发明还涉及使用抗体-药物结合物治疗疾病，例如癌症。
• Reverse Biosynthesis: Generating Combinatorial Pools of Drug Leads from Enzyme-Mediated Fragmentation of Natural Products
  作者：Tomas Richardson-Sanchez、William Tieu、Rachel Codd

  DOI：10.1002/cbic.201600636

  日期：2017.2.16

  desferrioxamine B (1) gave a pool of catabolites; subsequent derivatisation yielded a 5‐lipoxygenase inhibitor. This top‐down approach to generate new drug leads from a natural product, “reverse biosynthesis”, provides a new perspective on natural products as a resource for drug discovery.

  建设性破坏：天然产物去铁草胺B（1）的酶介导裂解产生大量的分解代谢产物。随后的衍生化产生了5-脂氧合酶抑制剂。这种从天然产物“逆向生物合成”产生新药线索的自上而下的方法为将天然产物作为发现药物的资源提供了新的视角。
• ZIRCONIUM-RADIOLABELED, CYSTEINE ENGINEERED ANTIBODY CONJUGATES
  申请人：Gill Herman

  公开号：US20100111856A1

  公开（公告）日：2010-05-06

  Antibodies are engineered by replacing one or more amino acids of a parent antibody with non cross-linked, highly reactive cysteine amino acids. Antibody fragments may also be engineered with one or more cysteine amino acids to form cysteine engineered antibody fragments (ThioFab). Methods of design, preparation, screening, and selection of the cysteine engineered antibodies are provided. Cysteine engineered antibodies (Ab) are conjugated with one or more zirconium complex (Z) labels through a linker (L) to form cysteine engineered zirconium-labeled antibody conjugates having Formula I: Ab-(L-Z) p I where p is 1 to 4. Imaging methods and diagnostic uses for zirconium-radiolabeled, cysteine engineered antibody conjugate compositions are disclosed.

  抗体是通过将一个或多个亲缘抗体的氨基酸替换为非交联、高反应性的半胱氨酸氨基酸来设计的。抗体片段也可以通过引入一个或多个半胱氨酸氨基酸来设计半胱氨酸工程抗体片段（ThioFab）。提供了设计、制备、筛选和选择半胱氨酸工程抗体的方法。半胱氨酸工程抗体（Ab）通过连接剂（L）与一个或多个锆配合物（Z）标记结合，形成具有公式I的半胱氨酸工程锆标记抗体结合物：Ab-（L-Z）pI，其中p为1至4。揭示了锆放射标记、半胱氨酸工程抗体结合物组合物的成像方法和诊断用途。
• Stoffwechselprodukte von Mikroorganismen 49. Mitteilung. Die Ferrioxamine A1, A2 und D2
  作者：W. Keller-Schierlein、P. Mertens、V. Prelog、A. Walser

  DOI：10.1002/hlca.19650480407

  日期：——

  AbstractThe structures of the ferrioxamines A1, A2, and D2, minor components of the sideramine mixtures from cultures of Streptomyces, have been determined by degradation and, in part, by synthesis. Whereas the previously investigated ferrioxamines B, D1, E, and G contain but a single basic component, 1‐amino‐5‐hydroxylaminopentane, the ferrioxamines A1, A2, and D2 contain in addition to this base its lower homologue, 1‐amino‐4‐hydroxylamino‐butane.