[Ag(1-(3-aminopropyl)imidazole)]ClO4 | 894775-74-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [Ag(1-(3-aminopropyl)imidazole)]ClO4
• CAS: 894775-74-7
• 化学式: C₆H₁₁AgN₃*ClO₄
• 分子量: 332.492
• InChiKey: XIYGIZYDFPPTKO-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  1-(3-氨基丙基)咪唑 、 高氯酸银水合物 以 乙醇 为溶剂， 以72%的产率得到[Ag(1-(3-aminopropyl)imidazole)]ClO4
  参考文献：
  名称：

  ‘Silver bullets’ in antimicrobial chemotherapy: Synthesis, characterisation and biological screening of some new Ag(I)-containing imidazole complexes

  摘要：

  Simple synthetic routes are given to the Ag(I) complexes, [Ag-2(imH)(4)](salH)(2) (imH = imidazole; salH(2) = salicylic acid), (Ag[MeNO(2)imH)(2)]ClO4 center dot nH(2)O (MeNO(2)imH = 2-methyl-5-nitroimidazole; n = 1, 3), [Ag(NO(2)im)] (NO(2)imH = 5-nitroimidazole) and [Ag-(apim)]ClO4 (apim =1-(3-aminopropyl)imidazole). X-ray crystal structures of [Ag-2(imH)(4)](salH)(2), [Ag(MeNO(2)imH)(2)]ClO4 center dot H2O and [Ag(apim)]ClO4 were obtained. The new Ag(I) complexes and related known Ag(I) imidazolates were screened for their growth inhibitory effects (in vitro) against the pathogenic bacteria methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli and also the fungal pathogen Candida albicans. [Ag-2(imH)(4)](salH)(2), in comparison to the prescription drug silver sulfadiazine, had significantly better anti-bacterial qualities, whilst against the fungus C albicans it was 47 times more potent than the marketed drug ketoconazole. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2005.11.021