Boc-D-Glu-OEt | 449171-15-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-D-Glu-OEt
• 英文别名: (4R)-4-[(tert-butoxycarbonyl)amino]-5-ethoxy-5-oxopentanoic acid；(4R)-5-ethoxy-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxopentanoic acid
• CAS: 449171-15-7
• 化学式: C₁₂H₂₁NO₆
• 分子量: 275.302
• InChiKey: LXQBXYDPJVHNPQ-MRVPVSSYSA-N

物化性质

• 沸点：
  439.0±40.0 °C(Predicted)
• 密度：
  1.159±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  19
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Boc-D-Glu-OEt 在 甲醇 、 N,N-二异丙基乙胺 、 bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate 、 三氟乙酸 、 sodium hydroxide 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.5h， 生成 D-Glu-γ-D-Glu
  参考文献：
  名称：

  γ-Glutamyl-dipeptides: Easy tools to rapidly probe the stereoelectronic properties of the ionotropic glutamate receptor binding pocket

  摘要：

  gamma-Glutamyl-dipeptides, built by condensing the distal carboxylate of L-Glu (or D-Glu) onto a series of differently functionalized amino acids, were prepared and used as tools for rapidly probing the stereo electronic properties of iGluRs, searching for subtype-selective ligands. (C) 2016 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2016.11.025

文献信息

• Synthesis of unusual isoxazoline containing <b>β</b> and <b>γ</b>-dipeptides as potential glutamate receptor ligands
  作者：Lucia Tamborini、Federica Mastronardi、Federica Dall'Oglio、Carlo De Micheli、Birgitte Nielsen、Leonardo Lo Presti、Paola Conti、Andrea Pinto

  DOI：10.1039/c5md00159e

  日期：——

  Unconventional beta and gamma dipeptides as tools to investigate the iGluR binding domain.

  非传统的β和γ二肽作为研究iGluR结合结构的工具。
• γ-Glutamyl-dipeptides: Easy tools to rapidly probe the stereoelectronic properties of the ionotropic glutamate receptor binding pocket
  作者：Lucia Tamborini、Veronica Nicosia、Paola Conti、Federica Dall'Oglio、Carlo De Micheli、Birgitte Nielsen、Anders A. Jensen、Darryl S. Pickering、Andrea Pinto

  DOI：10.1016/j.tet.2016.11.025

  日期：2016.12

  gamma-Glutamyl-dipeptides, built by condensing the distal carboxylate of L-Glu (or D-Glu) onto a series of differently functionalized amino acids, were prepared and used as tools for rapidly probing the stereo electronic properties of iGluRs, searching for subtype-selective ligands. (C) 2016 Elsevier Ltd. All rights reserved.