(S)-(+)-1-(4-aminophenyl)-1,2-ethanediol | 287944-34-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-(+)-1-(4-aminophenyl)-1,2-ethanediol
• 英文别名: (1S)-1-(4-aminophenyl)ethane-1,2-diol
• CAS: 287944-34-7
• 化学式: C₈H₁₁NO₂
• 分子量: 153.181
• InChiKey: ANIQOFHUNWJCPJ-MRVPVSSYSA-N

物化性质

• 沸点：
  390.2±27.0 °C(Predicted)
• 密度：
  1.273±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (S)-(+)-1-(4-aminophenyl)-1,2-ethanediol 在 吡啶 、 对甲苯磺酸 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 16.0h， 生成 (S)-(+)-N-(4-(2,2-dimethyl-1,3-dioxolan-4-yl)phenyl)methanesulfonamide
  参考文献：
  名称：

  Microbial transformation of 2-hydroxy and 2-acetoxy ketones with Geotrichum sp.

  摘要：

  Biotransformation of a series of o-, m- and p- substituted alpha-hydroxy - and alpha-acetoxyphenylethanones 1a-h and 9a-g with Geotrichum sp. led to the corresponding 1,2-diols 2 and/or monoacetates 10 in moderate to excellent enantiomeric excesses. alpha-Hydroxy- and alpha-acetoxyphenylethanones and their m- and p-derivatives gave preponderantly the S-configuration products while in the case of the o-derivatives R-alcohol was provided as the major enantiomer. The results of stereoselectivity were discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00023-7
• 作为产物：
  描述：

  2-羟基-1-(4-硝基苯基)-1-乙酮 在 platinum(IV) oxide Geotrichum sp 、 水 、 氢气 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 15.0h， 生成 (S)-(+)-1-(4-aminophenyl)-1,2-ethanediol
  参考文献：
  名称：

  Microbial transformation of 2-hydroxy and 2-acetoxy ketones with Geotrichum sp.

  摘要：

  Biotransformation of a series of o-, m- and p- substituted alpha-hydroxy - and alpha-acetoxyphenylethanones 1a-h and 9a-g with Geotrichum sp. led to the corresponding 1,2-diols 2 and/or monoacetates 10 in moderate to excellent enantiomeric excesses. alpha-Hydroxy- and alpha-acetoxyphenylethanones and their m- and p-derivatives gave preponderantly the S-configuration products while in the case of the o-derivatives R-alcohol was provided as the major enantiomer. The results of stereoselectivity were discussed. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00023-7

文献信息

• Silicon-containing resist underlayer film-forming composition and patterning process
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP2599818B1

  公开（公告）日：2017-02-01