α-L-aspartyl-L-phenylalanine ethyl ester | 22839-83-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: α-L-aspartyl-L-phenylalanine ethyl ester
• 英文别名: alfa-L-Aspartyl-L-phenylalanine ethyl ester；L-aspartyl-L-phenylalanine ethyl ester；Asp-Phe-Aethylester；Ethyl aspartylphenylalaninate；(3S)-3-amino-4-[[(2S)-1-ethoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid
• CAS: 22839-83-4
• 化学式: C₁₅H₂₀N₂O₅
• 分子量: 308.334
• InChiKey: SZXAXWBWWRMFNS-RYUDHWBXSA-N

物化性质

• 沸点：
  542.0±50.0 °C(Predicted)
• 密度：
  1.251±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  119
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (2S)-2-氨基-3-苯丙酸乙酯 在 钯 氢气 、 溶剂黄146 作用下， 以 乙酸乙酯 为溶剂， 生成 α-L-aspartyl-L-phenylalanine ethyl ester
  参考文献：
  名称：

  一些二肽的结构-味道关系。

  摘要：

  DOI：

  10.1021/ja01038a046

文献信息

• Method of removing formyl groups from N-formyl-amino acid and
  申请人：Ajinomoto Co., Inc.

  公开号：US04021418A1

  公开（公告）日：1977-05-03

  The masking N-formyl group of an N-formyl-amino acid ester or N-formyl-peptide ester is removed without major side reactions when the ester is reacted in an inert liquid medium with hydroxylamine of which at least 70% is present in the form of a salt with a strong acid, the remainder, if any, being present as the free base or the salt of a weak acid.

  当N-甲酰氨基酸酯或N-甲酰肽酯的酯基在惰性液体介质中与羟胺反应时，至少70%以强酸盐的形式存在的羟胺去除N-甲酰基团，而不会发生主要的副反应，剩余的羟胺（如果有的话）以弱酸的自由碱或盐的形式存在。
• A dipeptide sweetening composition
  申请人：AJINOMOTO CO., INC.

  公开号：EP0053844A1

  公开（公告）日：1982-06-16

  A dipeptide sweetening composition, comprising : (a) from 20 to 60 % by wt. of solid fat, (b) from 10 to 30 % by wt. of emulsifier, (c) from 10 to 30 % by wt. of polysaccharide and (d) not more than 30 % by wt. dipeptide sweetener, all of said percents being based on the weight of the composition, is stable against heat or enzymes and useful for processed and fermentation foods.

  一种二肽甜味剂组合物，包括 ： (a) 20%至 60%（重量百分比）的固体脂肪、 (b) 10%至 30%（重量百分比）的乳化剂、 (c) 10%至 30%（重量百分比）的多糖和 (d) 重量百分比不超过 30%的二肽甜味剂、 所有所述百分比均基于组合物的重量，对热或酶稳定，适用于加工食品和发酵食品。
• A dipeptide sweetening composition and its use for sweetening food, beverages or pharmaceutical compositions
  申请人：AJINOMOTO CO., INC.

  公开号：EP0060903A1

  公开（公告）日：1982-09-29

  The invention relates to a dipeptide sweetening composition, which comprises (a) 100% by wt. of dipeptide sweetener and (b) at least one kind of flavoring agents, in an amount sufficient to impart the tasting strength equal to that of 10 to 200% by wt. of monosodium L-glutamate based upon the weight of the dipeptide sweetener, selected from the group consisting of sodium glutamate, sodium inosine-5'-phosphate, sodium guanosine-5'-phosphate and sodium aspartate. This sweetening composition shows a greatly improved sweetness compared with dipeptide sweeteners alone and may be used for all sweetening purposes, such as sweetening food, beverages or pharmaceutical compositions.

  本发明涉及一种二肽甜味剂组合物，它包括 (a) 重量百分比为 100%的二肽甜味剂和 (b) 至少一种调味剂，其用量足以产生相当于以二肽甜味剂重量计 10%至 200%（以 L-谷氨酸钠重量计）的味觉强度，该调味剂选自谷氨酸钠、肌苷-5'-磷酸钠、鸟苷-5'-磷酸钠和天门冬氨酸钠组成的组。 与单独使用二肽甜味剂相比，这种甜味剂组合物的甜度大大提高，可用于所有甜味剂用途，如食品、饮料或药物组合物的甜味剂。
• Process for synthesizing peptides or peptide derivatives
  申请人：Imahori, Kazutomo

  公开号：EP0086053A1

  公开（公告）日：1983-08-17

  A process for synthesizing peptides or peptide derivatives is disclosed. The process involves using aminoacyl-tRNA synthetase as a condensing agent when synthesizing peptides or peptide derivatives from amino acids. According to the process, peptides or peptide derivatives which are useful as various hormones such as bradykinin having antihypertensive activity or somatostatin having an internal or external secretion controlling function and other biologically active substances such as antibiotic peptides or seasoning peptides can be produced at a moderate price without using protective groups.

  本发明公开了一种合成肽或肽衍生物的工艺。 该工艺涉及在从氨基酸合成肽或肽衍生物时使用氨基酰-tRNA 合成酶作为缩合剂。 根据该工艺，可以不使用保护基团，以适中的价格生产作为各种激素（如具有抗高血压活性的缓激肽或具有内外分泌控制功能的体生长激素）和其他生物活性物质（如抗生素肽或调味肽）的肽或肽衍生物。
• Process for preparation of aspartylphenylalanine alkyl esters
  申请人：TOYO SODA MANUFACTURING CO., LTD.

  公开号：EP0074095A1

  公开（公告）日：1983-03-16

  a-L-aspartylphenylalanine lower alkyl esters are prepared by a process wherein L-aspartic acid and a lower alkyl ester of L-phenylalanine are contacted with a culture or treated culture product of a microorganism belonging to the genus Pseudomonas, Alcaligenes, Torulopsis, Rhodotorula or Sporobolomyces and being capable of producing a a-L-aspartyl-L-phenylalanine lower alkyl ester from L-aspartic acid and a lower alkyl ester of L-phenylalanine.

  a-L-天冬氨酰-L-苯丙氨酸低级烷基酯的制备方法是：将 L-天冬氨酸和 L-苯丙氨酸低级烷基酯与假单胞菌属、钙铝菌属、拟鸟嘌呤菌属、罗多酵母菌属或孢子寡糖酵母菌属微生物的培养物或处理培养物接触，该微生物能从 L-天冬氨酸和 L-苯丙氨酸低级烷基酯中产生 a-L-天冬氨酰-L-苯丙氨酸低级烷基酯。