N-L-leucyl-L-phenylalanine ethyl ester; hydrochloride | 74973-89-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-L-leucyl-L-phenylalanine ethyl ester; hydrochloride
• 英文别名: N-L-Leucyl-L-phenylalanin-aethylester; Hydrochlorid；N-(L-leucyl)-L-phenylalanine ethyl ester hydrochloride；ethyl (2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-phenylpropanoate;hydrochloride
• CAS: 74973-89-0
• 化学式: C₁₇H₂₆N₂O₃*ClH
• 分子量: 342.866
• InChiKey: ZFBSEQOBVQZHDM-YYLIZZNMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.07
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  81.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (2S)-2-氨基-3-苯丙酸乙酯 在 盐酸 、 氯甲酸乙酯 、 钯 作用下， 生成 N-L-leucyl-L-phenylalanine ethyl ester; hydrochloride
  参考文献：
  名称：

  Synthesis of Peptides Related to Gramicidin S. IV.¹ Two Polypeptide Intermediates Containing L-Phenylalanine in Place of D-Phenylalanine²

  摘要：

  DOI：

  10.1021/ja01521a036

文献信息

• Phosphonyldipeptides useful in the treatment of cardiovascular diseases
  申请人：Zambon Group S.p.A.

  公开号：US05760285A1

  公开（公告）日：1998-06-02

  Compounds of formula (II) ##STR1## wherein R is a biphenyl group optionally substituted by one or more substituents, the same or different, selected among halogen atoms, hydroxy groups, alkoxy, alkyl or thioalkyl groups having from 1 to 6 carbon atoms in the alkyl moiety, carboxylic groups, nitro groups, amino, mono- or di-alkylamino groups having from 1 to 6 carbon atoms in the alkyl moiety; R.sub.1 is a hydrogen atom or a straight or branched C.sub.1 -C.sub.4 allyl; R.sub.2 is a straight or branched C.sub.1 -C.sub.6 alkyl or an arylalkyl having from 1 to 6 carbon atoms in the alkyl moiety wherein the aryl is a phenyl, a naphthyl or a 5 or 6 membered aromatic heterocycle with one or two heteroatoms selected among nitrogen, oxygen and sulphur, optionally substituted as above indicated for the R substituent; R.sub.3 is a straight or branched C.sub.1 -C.sub.6 alkyl, optionally containing one or more fluorine atoms, or an arylalkyl having from 1 to 6 carbon atoms in the alkyl moiety; the carbon atoms marked with an asterisk are asymmetric carbon atoms; and their pharmaceutically acceptable salts, are described. The compounds of formula (II) are useful in the treatment of cardiovascular diseases.

  公式（II）的化合物##STR1##其中R是一个联苯基团，可选择性地被一个或多个取代基取代，这些取代基相同或不同，包括卤素原子、羟基、烷氧基、烷基或硫代烷基，其烷基部分有1至6个碳原子，羧基、硝基、氨基、单烷基或二烷基氨基，其烷基部分有1至6个碳原子；R.sub.1是氢原子或直链或支链C.sub.1-C.sub.4丙烯基；R.sub.2是直链或支链C.sub.1-C.sub.6烷基或含有1至6个碳原子的芳基烷基，其中芳基是苯基、萘基或带有1个或2个杂原子（氮、氧和硫）的5或6元芳香杂环，可选择性地按上述R取代基取代；R.sub.3是直链或支链C.sub.1-C.sub.6烷基，可选择性地含有一个或多个氟原子，或含有1至6个碳原子的芳基烷基；带有星号的碳原子是不对称碳原子；以及它们的药学上可接受的盐。公式（II）的化合物在心血管疾病的治疗中有用。
• Izumiya; Fruton, Journal of Biological Chemistry, 1956, vol. 218, p. 59,70
  作者：Izumiya、Fruton

  DOI：——

  日期：——
• PHOSPHONYLDIPEPTIDES USEFUL IN THE TREATMENT OF CARDIOVASCULAR DISEASES
  申请人：ZAMBON GROUP S.p.A.

  公开号：EP0755405A1

  公开（公告）日：1997-01-29
• US5760285A
  申请人：——

  公开号：US5760285A

  公开（公告）日：1998-06-02
• [EN] PHOSPHONYLDIPEPTIDES USEFUL IN THE TREATMENT OF CARDIOVASCULAR DISEASES<br/>[FR] PHOSPHONYLDIPEPTIDES UTILES DANS LE TRAITEMENT DE MALADIES CARDIO-VASCULAIRES
  申请人：ZAMBON GROUP S.P.A.

  公开号：WO1995028417A1

  公开（公告）日：1995-10-26

  (EN) Compounds of formula (II) wherein R is a biphenyl group optionally substituted by one or more substituents, the same or different, selected among halogen atoms, hydroxy groups, alkoxy, alkyl or thioalkyl groups having from 1 to 6 carbon atoms in the alkyl moiety, carboxylic groups, nitro groups, amino, mono- or di-alkylamino groups having from 1 to 6 carbon atoms in the alkyl moiety; R1 is a hydrogen atom or a straight or branched C1-C4 alkyl; R2 is a straight or branched C1-C6 alkyl or an arylalkyl having from 1 to 6 carbon atoms in the alkyl moiety wherein the aryl is a phenyl, a naphthyl or a 5 or 6 membered aromatic heterocycle with one or two heteroatoms selected among nitrogen, oxygen and sulphur, optionally substituted as above indicated for the R substituent; R3 is a straight or branched C1-C6 alkyl, optionally containing one or more fluorine atoms, or an arylalkyl having from 1 to 6 carbon atoms in the alkyl moiety; the carbon atoms marked with an asterisk are asymmetric carbon atoms; and their pharmaceutically acceptable salts, are described. The compounds of formula (II) are useful in the treatment of cardiovascular diseases.(FR) Composés de la formule (II), ainsi que leurs sels acceptables sur le plan pharmacologique, dans laquelle R représente un groupe diphényle éventuellement substitué par un ou plusieurs substituants, semblables ou différents, choisis parmi des atomes d'halogène, des groupes hydroxy, alcoxy, des groupes alcoyle ou thioalcoyle possédant de 1 à 6 atomes de carbone dans la fraction alcoyle, des groupes carboxyliques, des groupes nitro, des groupes amino, mono ou dialcoylamino possédant de 1 à 6 atomes de carbone dans la fraction alcoyle; R1 représente un atome d'hydrogène ou un alcoyle C1-C4 droit ou ramifié; R2 représente un alcoyle C1-C6 droit ou ramifié ou un arylalcoyle possédant de 1 à 6 atomes de carbone dans la fraction alcoyle, où aryle représente phényle, naphtyle ou un hétérocycle aromatique à 5 ou 6 chaînons dont un ou deux hétéroatomes sont choisis parmi azote, oxygène et soufre, et sont éventuellement substitués comme indiqué ci-dessus pour le substituant de R; R3 représente alcoyle C1-C6 droit ou ramifié, éventuellement contenant un ou plusieurs atomes de fluor, ou un arylalcoyle possédant de 1 à 6 atomes de carbone dans la fraction alcoyle; les atomes de carbone marqués à l'aide d'un astérisque étant des atomes de carbone asymétriques. Les composés de la formule (II) sont utiles dans le traitement de maladies cardio-vasculaires.