trifluoroacetic pivalic anhydride | 55108-33-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: trifluoroacetic pivalic anhydride
• 英文别名: (2,2,2-Trifluoroacetyl) 2-methylpropanoate
• CAS: 55108-33-3
• 化学式: C₆H₇F₃O₃
• 分子量: 184.115
• InChiKey: RSFHKSGYZKQIOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  三氟过氧乙酸 、 trifluoroacetic pivalic anhydride 以 三氟乙酸 为溶剂， 生成 异丙基(三氟甲基)过氧酸酐
  参考文献：
  名称：

  Heterolytic decarboxylation involving acyltrifluoroacetyl peroxide intermediates

  摘要：

  Selective carboxylic acid decarboxylation was elaborated. Generation of acyltrifluoroacetyl peroxides from carboxylic peracids and trifluoroacetyl anhydride (Method A), as well as from trifluoroperacetic acid and acyltrifluoroacetyl anhydride (Method B), leads to simultaneous peroxide decomposition into the corresponding alkyltrifluoroacetates. DFT computations, as well as experimental data, support an acid-catalyzed heterolytic mechanism for acyltrifluoroacetyl peroxide decomposition. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)02151-2
• 作为产物：
  描述：

  三氟乙酸酐 、 异丁酸 生成 trifluoroacetic pivalic anhydride
  参考文献：
  名称：

  Dmitrevskaya, L. I.; Kurkovskaya, L. N.; Ponomarenko, N. K., Journal of Organic Chemistry USSR (English Translation), 1983, p. 1987 - 1989

  摘要：

  DOI：

文献信息

• The Development of a Convergent and Efficient Enantioselective Synthesis of the Bengamides via a Common Polyol Intermediate
  作者：Robert K. Boeckman, Jr.、Tammy J. Clark、Brian C. Shook

  DOI：10.1002/hlca.200290026

  日期：2002.12

  the bengamide family of antitumor agents from a common polyol thioester is described. Consecutive aldol condensations afford the protected polyol thioester side chain suitable for coupling to the bengamides. A novel chiral-phase-transfer-catalyzed enantioselective alkylation affords the properly functionalized caprolactams required for the synthesis of more-complex members of the bengamide family. Use

  描述了一种从普通的多元醇硫酯到抗肿瘤剂苯甲酰胺家族的有效，通用的合成途径。连续的醛醇缩合得到适合于偶联至苯甲酰胺的被保护的多元醇硫酯侧链。一种新颖的手性相转移催化的对映选择性烷基化提供了合成苯甲酰胺家族中更复杂成员所需的适当官能化的己内酰胺。与对映选择性的羟醛缩合所需的硼路易斯酸相容的甲基2-萘基醚保护基的使用，可直接获得所有的苯甲酰胺。
• [EN] CD33 LIGANDS SUITABLE FOR INCORPORATION INTO CARRIERS<br/>[FR] LIGANDS CD33 APPROPRIÉS POUR ÊTRE INCORPORÉS DANS DES SUPPORTS
  申请人：GLYCOMIMETICS INC

  公开号：WO2021222767A1

  公开（公告）日：2021-11-04

  CD33 ligands which are useful for the synthesis of CD33 ligand-bearing carriers, wherein said CD33 ligand-bearing carriers are directly or indirectly linked to or associated with at least one anti-cancer agent, are described herein. Uses of said CD33 ligand-bearing carriers for treating and/or preventing a disease, disorder, or condition such as acute myeloid leukemia (AML) are also described. The ligands have formula (I) below.

  本文描述了用于合成携带CD33配体的载体的CD33配体，其中所述CD33配体携带的载体与至少一种抗癌剂直接或间接地连接或关联。本文还描述了使用所述CD33配体携带的载体治疗和/或预防疾病、障碍或状况，例如急性髓系白血病（AML）。该配体具有以下式子（I）的公式。
• [EN] E-SELECTIN TARGETING AGENTS<br/>[FR] AGENTS DE CIBLAGE DE LA SÉLECTINE E
  申请人：GLYCOMIMETICS INC

  公开号：WO2022061168A1

  公开（公告）日：2022-03-24

  E-selectin ligands which are useful for the synthesis of E-selectin ligand-bearing carriers,wherein said E-selectin ligand-bearing carriers are directly or indirectly linked to or associated with at least one therapeutic agent, diagnostic agent, imaging agent, or radiopharmaceutical are described herein.

  本文描述了用于合成具有E-selectin配体的载体的E-selectin配体配体，其中所述的E-selectin配体载体直接或间接地与至少一种治疗剂、诊断剂、成像剂或放射性药物相关联或连接。
• Best, Wayne M.; Cook, Anthony P. F.; Russell, James J., Journal of the Chemical Society. Perkin transactions I, 1986, p. 1139 - 1144
  作者：Best, Wayne M.、Cook, Anthony P. F.、Russell, James J.、Widdowson, David A.

  DOI：——

  日期：——
• Dmitrevskaya, L. I.; Kurkovskaya, L. N.; Ponomarenko, N. K., Journal of Organic Chemistry USSR (English Translation), 1983, p. 1987 - 1989
  作者：Dmitrevskaya, L. I.、Kurkovskaya, L. N.、Ponomarenko, N. K.、Usorov, M. I.、Smushkevich, Yu. I.、Suvorov, N. M.

  DOI：——

  日期：——