Ac-Met-Asp-Pro-OH | 142606-26-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ac-Met-Asp-Pro-OH
• 英文别名: (2S)-1-[(2S)-2-[[(2S)-2-acetamido-4-methylsulfanylbutanoyl]amino]-3-carboxypropanoyl]pyrrolidine-2-carboxylic acid
• CAS: 142606-26-6
• 化学式: C₁₆H₂₅N₃O₇S
• 分子量: 403.456
• InChiKey: DVCXMHBDRWOGDE-SRVKXCTJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  27
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  178
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  L-脯氨酸苄酯盐酸盐 在 对甲酚 、 茴香硫醚 、 氢氟酸 、 苯甲醚 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.17h， 生成 Ac-Met-Asp-Pro-OH
  参考文献：
  名称：

  Amino Acids and Peptides. XXXIII. Synthesis of N-Terminal Epitope Peptides of Mammalian Metallothioneins(MTs).

  摘要：

  In order to determine the fine structure of the mammalian metallothionein (MT) epitope to a monoclonal anti-rat Zn-MT-II antibody (MT 189-14-7), N-terminal peptides of various lengths of mammalian metallothioneins (MTs) were synthesized by a conventional solution method using the newly developed beta-2-adamantylaspartate, and their immunological properties were examined. It was found that the N-terminal acetyl group was indispensable for the reaction with the monoclonal antibody and the N-terminally acetylated pentapeptide, Ac-Met-Asp-Pro-Asn-Cys-OH, was the smallest peptide which exhibited a significant reactivity with the antibody.

  DOI：

  10.1248/cpb.40.1029

文献信息

• Amino Acids and Peptides. XXXIII. Synthesis of N-Terminal Epitope Peptides of Mammalian Metallothioneins(MTs).
  作者：Yoshio OKADA、Shigeru NAKAYAMA、Shin IGUCHI、Yutaka KIKUCHI、Masachika IRIE、Jun-ichi SAWADA、Hideharu IKEBUCHI、Tadao TERAO

  DOI：10.1248/cpb.40.1029

  日期：——

  In order to determine the fine structure of the mammalian metallothionein (MT) epitope to a monoclonal anti-rat Zn-MT-II antibody (MT 189-14-7), N-terminal peptides of various lengths of mammalian metallothioneins (MTs) were synthesized by a conventional solution method using the newly developed beta-2-adamantylaspartate, and their immunological properties were examined. It was found that the N-terminal acetyl group was indispensable for the reaction with the monoclonal antibody and the N-terminally acetylated pentapeptide, Ac-Met-Asp-Pro-Asn-Cys-OH, was the smallest peptide which exhibited a significant reactivity with the antibody.