2-(2,6,6-Trimethyl-3,6-dihydro-2H-pyran-2-yl)-ethanol | 170240-67-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 2-(2,6,6-Trimethyl-3,6-dihydro-2H-pyran-2-yl)-ethanol
• 英文别名: 2-(2,6,6-trimethyl-3H-pyran-2-yl)ethanol
• CAS: 170240-67-2
• 化学式: C₁₀H₁₈O₂
• 分子量: 170.252
• InChiKey: BADFVABAIWHYTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  叔丁基二苯基氯硅烷 、 2-(2,6,6-Trimethyl-3,6-dihydro-2H-pyran-2-yl)-ethanol 在 咪唑 、 4-二甲氨基吡啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以86%的产率得到tert-Butyl-diphenyl-[2-(2,6,6-trimethyl-3,6-dihydro-2H-pyran-2-yl)-ethoxy]-silane
  参考文献：
  名称：

  The use of acyclic monoterpenes in the preparation of β-pyrones: Synthesis of the right-hand fragment of Usneoidone E

  摘要：

  The right hand fragment, 36, of Usneoidone E, 1, a powerful antiviral and antitumoural agent has been synthesized from the beta-pyrone 32. Using linalool as starting material, a 2,2,6,6-tetrasubstituted dihydropyrane 20, precursor of 32 and 33, was prepared. 20 was also synthesized From geranyl acetate through selenide 7, and is a versatile precursor for the synthesis of tetaprenyltoluquinols. Unambiguous C-13 NMR assignment has been done by 2D correlations.

  DOI：

  10.1016/0040-4020(95)00084-l
• 作为产物：
  描述：

  6-ethenyl-2,2,6-trimethyl-3-(phenylseleno)tetrahydropyran 在 sodium hydroxide 、 硼烷 、 双氧水 作用下， 生成 2-(2,6,6-Trimethyl-3,6-dihydro-2H-pyran-2-yl)-ethanol
  参考文献：
  名称：

  The use of acyclic monoterpenes in the preparation of β-pyrones: Synthesis of the right-hand fragment of Usneoidone E

  摘要：

  The right hand fragment, 36, of Usneoidone E, 1, a powerful antiviral and antitumoural agent has been synthesized from the beta-pyrone 32. Using linalool as starting material, a 2,2,6,6-tetrasubstituted dihydropyrane 20, precursor of 32 and 33, was prepared. 20 was also synthesized From geranyl acetate through selenide 7, and is a versatile precursor for the synthesis of tetaprenyltoluquinols. Unambiguous C-13 NMR assignment has been done by 2D correlations.

  DOI：

  10.1016/0040-4020(95)00084-l