4,6-di(thiophen-2-yl)-3,4-dihydropyridin-2(1H)-one | 1586790-06-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4,6-di(thiophen-2-yl)-3,4-dihydropyridin-2(1H)-one
• 英文别名: 4,6-dithiophen-2-yl-3,4-dihydro-1H-pyridin-2-one
• CAS: 1586790-06-8
• 化学式: C₁₃H₁₁NOS₂
• 分子量: 261.368
• InChiKey: UKZFWGFMGYFPKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  85.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,3-二-2-噻吩基-2-丙烯醛基-1-酮 在 potassium tert-butylate 、 ammonium acetate 、 苄基三乙基氯化铵 、 溶剂黄146 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 20.0h， 生成 4,6-di(thiophen-2-yl)-3,4-dihydropyridin-2(1H)-one
  参考文献：
  名称：

  Synthesis, Characterization, and Antibacterial Activity of Novel Pyridones

  摘要：

  Novel ethyl 2-oxo-4,6-diaryl-1,2,3,4-tetrahydropyridine-3-carboxylate and 4,6-diaryl-3,4-dihydropyridine-2(1H)-one derivatives have been synthesized from the cyclization of adducts of diethylmalonate to chalcones with ammonium acetate. The structures were established on the basis of extensive spectroscopic methods and further confirmed by X-ray crystallographic analysis. Antibacterial activity of obtained pyridones was investigated against four human pathogen microorganisms and the compounds showed poor activity.[Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]

  DOI：

  10.1080/00397911.2013.845902

文献信息

• Synthesis, Characterization, and Antibacterial Activity of Novel Pyridones
  作者：Hayreddin Gezegen、Mustafa Ceylan、İsa Karaman、Ertan Şahin

  DOI：10.1080/00397911.2013.845902

  日期：2014.4.18

  Novel ethyl 2-oxo-4,6-diaryl-1,2,3,4-tetrahydropyridine-3-carboxylate and 4,6-diaryl-3,4-dihydropyridine-2(1H)-one derivatives have been synthesized from the cyclization of adducts of diethylmalonate to chalcones with ammonium acetate. The structures were established on the basis of extensive spectroscopic methods and further confirmed by X-ray crystallographic analysis. Antibacterial activity of obtained pyridones was investigated against four human pathogen microorganisms and the compounds showed poor activity.[Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]