1,1'-diallyl-5,5'-dimethyl-1H,1'H-2,3'-biindole | 1262228-32-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1,1'-diallyl-5,5'-dimethyl-1H,1'H-2,3'-biindole
• 英文别名: 5-Methyl-2-(5-methyl-1-prop-2-enylindol-3-yl)-1-prop-2-enylindole
• CAS: 1262228-32-9
• 化学式: C₂₄H₂₄N₂
• 分子量: 340.468
• InChiKey: ZSPQRYGHPOJHDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  9.9
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  1-allyl-5-methyl-1H-indole 在 碘 、 碳酸氢钠 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 8.0h， 以61%的产率得到1,1'-diallyl-5,5'-dimethyl-1H,1'H-2,3'-biindole
  参考文献：
  名称：

  Iodine-Induced Regioselective C−C and C−N Bonds Formation of N-Protected Indoles

  摘要：

  A mild, metal-free, and environmently benign iodine-promoted regioselective C-C and C-N bonds formation of N-protected indole derivatives giving 2,3'-biindoles 2 and 4-(1H-indol-2-yl)morpholines 4 is successfully demonstrated. Various bioactive 2,3'-biindoles and 4-(1H-indol-2-yl)morpholines, bearing electron-rich to moderately electron-poor substituents, can be prepared in moderate to good yields.

  DOI：

  10.1021/jo1023014

文献信息

• Iodine-Induced Regioselective C−C and C−N Bonds Formation of <i>N</i>-Protected Indoles
  作者：Ying-Xiu Li、Ke-Gong Ji、Hai-Xi Wang、Shaukat Ali、Yong-Min Liang

  DOI：10.1021/jo1023014

  日期：2011.1.21

  A mild, metal-free, and environmently benign iodine-promoted regioselective C-C and C-N bonds formation of N-protected indole derivatives giving 2,3'-biindoles 2 and 4-(1H-indol-2-yl)morpholines 4 is successfully demonstrated. Various bioactive 2,3'-biindoles and 4-(1H-indol-2-yl)morpholines, bearing electron-rich to moderately electron-poor substituents, can be prepared in moderate to good yields.