1-deoxy-L-glycero-D-galacto-heptitol | 134002-90-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1-deoxy-L-glycero-D-galacto-heptitol
• 英文别名: 7-deoxy-L-glycero-D-glucoheptitol；7-Desoxy-L-glycero-D-glucoheptit；1-Desoxy-L-glycero-D-galaktoheptit；L-Galakto-D-heptomethylit；(2S,3R,4R,5R,6S)-Heptane-1,2,3,4,5,6-hexaol；(2S,3R,4R,5R,6S)-heptane-1,2,3,4,5,6-hexol
• CAS: 134002-90-7
• 化学式: C₇H₁₆O₆
• 分子量: 196.2
• InChiKey: CCLARULDIPFTCP-PAMBMQIZSA-N

物化性质

• 沸点：
  536.6±45.0 °C(Predicted)
• 密度：
  1.497±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.7
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  121
• 氢给体数：
  6
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-deoxy-L-glycero-D-galacto-heptitol 在 对甲苯磺酸 作用下， 以 丙酮 为溶剂， 反应 2.0h， 生成 1-deoxy-2,3:4,5:6,7-tri-O-isopropylidene L-glycero-D-galacto-heptitol
  参考文献：
  名称：

  l-Fucose from Vitamin C with Only Acetonide Protection

  摘要：

  Addition of human milk oligosaccharides (HMO) to baby foods may protect infants from disease. As many simple HMOs are fucosylated this is likely to increase the demand for L-fucose as a synthetic building block. Any chemical synthesis must be cheap to compete with a biotechnological process. Acetonide is the only protecting group we have used in this new synthesis of L-fucose from vitamin C in 27% overall yield (purification by recrystallization; no chromatography required in the entire sequence).

  DOI：

  10.1021/ol502733x
• 作为产物：
  描述：

  7-deoxy-L-glycero-D-gluco-heptose 在 sodium amalgam 作用下， 生成 1-deoxy-L-glycero-D-galacto-heptitol
  参考文献：
  名称：

  Votocek, Collection of Czechoslovak Chemical Communications, 1938, vol. 10, p. 273,276

  摘要：

  DOI：

文献信息

• <scp>l</scp>-Fucose from Vitamin C with Only Acetonide Protection
  作者：Zilei Liu、Akihide Yoshihara、Mark R. Wormald、Sarah F. Jenkinson、Vicky Gibson、Ken Izumori、George W. J. Fleet

  DOI：10.1021/ol502733x

  日期：2014.11.7

  Addition of human milk oligosaccharides (HMO) to baby foods may protect infants from disease. As many simple HMOs are fucosylated this is likely to increase the demand for L-fucose as a synthetic building block. Any chemical synthesis must be cheap to compete with a biotechnological process. Acetonide is the only protecting group we have used in this new synthesis of L-fucose from vitamin C in 27% overall yield (purification by recrystallization; no chromatography required in the entire sequence).
• Votocek, Collection of Czechoslovak Chemical Communications, 1938, vol. 10, p. 273,276
  作者：Votocek

  DOI：——

  日期：——