3-(6-氨基-2-吡啶基)丙腈 | 153140-17-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 3-(6-氨基-2-吡啶基)丙腈
• 英文名称: 2-Amino-6-(2-cyanoethyl)pyridine
• 英文别名: 3-(6-aminopyridin-2-yl)propanenitrile
• CAS: 153140-17-1
• 化学式: C₈H₉N₃
• mdl: MFCD18816575
• 分子量: 147.18
• InChiKey: XZCDNYLQUPGUGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  62.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(6-氨基-2-吡啶基)丙腈 在 二甲胺基甲硼烷 、 溶剂黄146 作用下， 以 溶剂黄146 为溶剂， 反应 2.0h， 生成 O-α-D-Glucopyranosyl-(1->4)-O-α-D-glucopyranosyl-(1->4)-1-deoxy-1-<(6-cyanoethyl-2-pyridyl)amino>-D-glucitol
  参考文献：
  名称：

  Fukase, Koichi; Nakayama, Hideo; Kurosawa, Motohiro, Journal of Carbohydrate Chemistry, 1994, vol. 13, # 5, p. 715 - 736

  摘要：

  DOI：
• 作为产物：
  描述：

  3-(6-Tritylamino-2-pyridyl)-2-propenenitrile 在 钯 氢气 、 溶剂黄146 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 25.0 ℃ 、607.95 kPa 条件下， 反应 96.0h， 生成 3-(6-氨基-2-吡啶基)丙腈
  参考文献：
  名称：

  Fukase, Koichi; Nakayama, Hideo; Kurosawa, Motohiro, Journal of Carbohydrate Chemistry, 1994, vol. 13, # 5, p. 715 - 736

  摘要：

  DOI：

文献信息

• COMPOSITION, METHOD FOR PREPARING SUGAR CHAIN SAMPLE, AND METHOD FOR ANALYZING SUGAR CHAIN
  申请人：Sumitomo Bakelite Co.,Ltd.

  公开号：EP3096136A1

  公开（公告）日：2016-11-23

  A composition is provided, including: polymer particles having a functional group for capturing a sugar chain, wherein the rate of change of mass calculated by Equation (F1) below is more than 90% and less than 112%. Rate of change%=A/B×100 [In Equation (F1), A represents the mass of the composition after incubation for 4 hours under an environment of a relative humidity of 50% and a temperature of 25°C, and B represents the mass of the composition before the incubation.

  本发明提供了一种组合物，包括：具有用于捕获糖链的官能团的聚合物颗粒，其中按以下公式（F1）计算的质量变化率大于 90%，小于 112%。变化率%=A/B×100 [在公式（F1）中，A 表示在相对湿度为 50%、温度为 25°C 的环境下培养 4 小时后组合物的质量，B 表示培养前组合物的质量。
• DIAGNOSIS OF MPS I DISORDERS BY MEASURING NON-REDUCING ENDS OF GAGS AFTER ENZYMATIC DIGEST
  申请人：BioMarin Pharmaceutical Inc.

  公开号：EP3232193A2

  公开（公告）日：2017-10-18

  Provided herein are processes for detecting oligosaccharides in a biological sample. In specific instances, the biological sample is provided from an individual suffering from a disorder associated with abnormal glycosaminoglycan accumulation.

  本文提供了检测生物样本中低聚糖的方法。在特定情况下，生物样本由患有与糖胺聚糖异常积累相关的疾病的人提供。
• DIAGNOSIS OF MPS IIIB DISORDERS BY MEASURING NON-REDUCING ENDS OF GAGS AFTER ENZYMATIC DIGEST
  申请人：BioMarin Pharmaceutical Inc.

  公开号：EP3264080A2

  公开（公告）日：2018-01-03

  Provided herein are methods of diagnosing or monitoring the treatment of abnormal glycan accumulation or a disorder associated with abnormal glycan accumulation.

  本文提供了诊断或监测异常聚糖积累或与异常聚糖积累相关的疾病的治疗方法。
• METHOD FOR PREPARING SUGAR CHAIN
  申请人：Sumitomo Bakelite Co., Ltd.

  公开号：EP3432000A1

  公开（公告）日：2019-01-23

  Provided is a method for preparing a sugar chain, including: a labeling step of adding a labeling reagent to a sugar chain-containing sample which contains a sugar chain to obtain a labeled product containing a labeled substance of the sugar chain, in which a reaction environment of the labeling reagent and the sugar chain contains water in the labeling step.

  本发明提供了一种制备糖链的方法，包括：在含有糖链的样品中加入标记试剂以获得含有糖链标记物质的标记产品的标记步骤，在标记步骤中，标记试剂和糖链的反应环境中含有水。
• METHOD, KIT, AND DEVICE FOR PREPARING GLYCAN FROM GLYCOPROTEIN
  申请人：NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

  公开号：EP3896074A1

  公开（公告）日：2021-10-20

  Provided are a method for preparing a glycan from a glycoprotein, and a kit and a device for preparing a glycan from a glycoprotein. The method includes (I) a step of obtaining a glycan-containing sample by bringing a glycan releasing solution that contains a hydroxylamine compound and a basic reagent into contact with the glycoprotein and releasing the glycan from the glycoprotein; (II) a step of adsorbing a glycan having a length of a monosaccharide or more on a purifying agent for purifying the glycan by bringing the glycan-containing sample into contact with the purifying agent, which is composed of a compound having a betaine structure; and (III) a step of eluting the glycan from the purifying agent.

  本发明提供了一种从糖蛋白中制备聚糖的方法，以及一种从糖蛋白中制备聚糖的试剂盒和装置。该方法包括 (I) 通过使含有羟胺化合物和碱性试剂的聚糖释放溶液与糖蛋白接触并从糖蛋白中释放聚糖，从而获得含聚糖样品的步骤；(III) 从纯化剂中洗脱聚糖。