1-(1-Ethylpropyl)-3-methyl-1H-pyrazol-5-amine | 1015845-99-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(1-Ethylpropyl)-3-methyl-1H-pyrazol-5-amine
• 英文别名: 5-methyl-2-pentan-3-ylpyrazol-3-amine
• CAS: 1015845-99-4
• 化学式: C₉H₁₇N₃
• 分子量: 167.25
• InChiKey: LXCXTVZKWPDDQF-UHFFFAOYSA-N

物化性质

• 沸点：
  278.8±20.0 °C(Predicted)
• 密度：
  1.05±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] SUBSTITUTED PYRAZOLO[3,4-B]PYRIDIN-6-CARBOXYLIC ACIDS AND THEIR USE<br/>[FR] ACIDES PYRAZOLO[3,4-B]PYRIDIN-6-CARBOXYLIQUES SUBSTITUÉS ET LEUR UTILISATION
  申请人：ABBVIE S À R L

  公开号：WO2017060873A1

  公开（公告）日：2017-04-13

  The present invention provides for compounds of formula (I), wherein R1, R2, R3, and R4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions mediated and modulated by CFTR, including cystic fibrosis, Sjögren's syndrome, pancreatic insufficiency, chronic obstructive lung disease, and chronic obstructive airway disease. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).