1,2,3-Trimethoxy-6,7-dimethyl-5-(3,4,5-trimethoxyphenyl)naphthalene | 1026070-59-6

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 芳基萘木脂素
• 英文名称: 1,2,3-Trimethoxy-6,7-dimethyl-5-(3,4,5-trimethoxyphenyl)naphthalene
• CAS: 1026070-59-6
• 化学式: C₂₄H₂₈O₆
• 分子量: 412.483
• InChiKey: HTYHMAMJXVCTJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  sacidumlignan A 、 碘甲烷 在 sodium carbonate 作用下， 以 丙酮 为溶剂， 反应 24.0h， 以15 mg的产率得到1,2,3-Trimethoxy-6,7-dimethyl-5-(3,4,5-trimethoxyphenyl)naphthalene
  参考文献：
  名称：

  Lignans and Their Degraded Derivatives from Sarcostemma acidum

  摘要：

  Four lignans, sacidumlignans A-D (1-4), and two degraded lignan derivatives, sacidumols A (5) and B (6), along with four known compounds, (+)-pinoresinol, 9alpha-hydroxypinoresinol, perforatic acid, and peucenine-7-O-methyl ether, were isolated from the ethanolic extract of the whole plant of Sarcostemma acidum. The structures and relative configuration of these new compounds were elucidated on the basis of spectroscopic and chemical data, especially 2D NMR techniques. Sacidumlignan D (4) was assigned as a rearranged tetrahydrofuran lignan with an unprecedented skeleton. Sacidumlignan A (1) showed moderate antimicrobial activities against two Gram-positive bacteria in vitro.

  DOI：

  10.1021/np049681s

文献信息

• Lignans and Their Degraded Derivatives from <i>Sarcostemma </i><i>a</i><i>cidum</i>
  作者：Li-She Gan、Sheng-Ping Yang、Cheng-Qi Fan、Jian-Min Yue

  DOI：10.1021/np049681s

  日期：2005.2.1

  Four lignans, sacidumlignans A-D (1-4), and two degraded lignan derivatives, sacidumols A (5) and B (6), along with four known compounds, (+)-pinoresinol, 9alpha-hydroxypinoresinol, perforatic acid, and peucenine-7-O-methyl ether, were isolated from the ethanolic extract of the whole plant of Sarcostemma acidum. The structures and relative configuration of these new compounds were elucidated on the basis of spectroscopic and chemical data, especially 2D NMR techniques. Sacidumlignan D (4) was assigned as a rearranged tetrahydrofuran lignan with an unprecedented skeleton. Sacidumlignan A (1) showed moderate antimicrobial activities against two Gram-positive bacteria in vitro.