(2S,5S,6R)-2-((S)-1-(3-methylbut-3-enyloxy)ethyl)-2-hydroxy-4,5-dimethyl-6-phenylmorpholin-3-one | 916606-97-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: (2S,5S,6R)-2-((S)-1-(3-methylbut-3-enyloxy)ethyl)-2-hydroxy-4,5-dimethyl-6-phenylmorpholin-3-one
• 英文别名: (2S,5S,6R)-2-hydroxy-4,5-dimethyl-2-[(1S)-1-(3-methylbut-3-enoxy)ethyl]-6-phenylmorpholin-3-one
• CAS: 916606-97-8
• 化学式: C₁₉H₂₇NO₄
• 分子量: 333.428
• InChiKey: WRLRKMLAFADIQN-MRHSLFKSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  59
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2S,5S,6R)-2-((S)-1-(3-methylbut-3-enyloxy)ethyl)-2-hydroxy-4,5-dimethyl-6-phenylmorpholin-3-one 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 三氟化硼乙醚 、 氨 、 sodium 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 48.05h， 生成 (Z,2R,3S)-3,4,7,8-tetrahydro-3-hydroxy-N,2,6-trimethyl-2H-oxocine-3-carboxamide
  参考文献：
  名称：

  Enantioselective Synthesis of Functionalized Medium-Sized Oxacycles

  摘要：

  Enantioselective routes to functionalized, seven-, eight-, and nine-membered oxacycles that are amenable to further elaboration have been developed. Salient features of the methodology include highly diastereoselective and regioselective transformations of an ephedrine-derived epoxy morpholinone to functionalized precursors of the oxacycles. The ephedrine scaffold exerts remote stereocontrol in the functionalization of the appended oxacycle.

  DOI：

  10.1021/ol062484v
• 作为产物：
  描述：

  (Z,5S,6R)-2-ethylidene-4,5-dimethyl-6-phenylmorpholin-3-one 在 sodium hydride 、 间氯过氧苯甲酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 4.0h， 生成 (2S,5S,6R)-2-((S)-1-(3-methylbut-3-enyloxy)ethyl)-2-hydroxy-4,5-dimethyl-6-phenylmorpholin-3-one
  参考文献：
  名称：

  Enantioselective Synthesis of Functionalized Medium-Sized Oxacycles

  摘要：

  Enantioselective routes to functionalized, seven-, eight-, and nine-membered oxacycles that are amenable to further elaboration have been developed. Salient features of the methodology include highly diastereoselective and regioselective transformations of an ephedrine-derived epoxy morpholinone to functionalized precursors of the oxacycles. The ephedrine scaffold exerts remote stereocontrol in the functionalization of the appended oxacycle.

  DOI：

  10.1021/ol062484v

文献信息

• Enantioselective Synthesis of Functionalized Medium-Sized Oxacycles
  作者：Sunil V. Pansare、Vikrant A. Adsool

  DOI：10.1021/ol062484v

  日期：2006.12.1

  Enantioselective routes to functionalized, seven-, eight-, and nine-membered oxacycles that are amenable to further elaboration have been developed. Salient features of the methodology include highly diastereoselective and regioselective transformations of an ephedrine-derived epoxy morpholinone to functionalized precursors of the oxacycles. The ephedrine scaffold exerts remote stereocontrol in the functionalization of the appended oxacycle.