methyl (2S)-2-[(2,2,2-trifluoroacetyl)amino]hex-5-enoate | 481067-73-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (2S)-2-[(2,2,2-trifluoroacetyl)amino]hex-5-enoate
• CAS: 481067-73-6
• 化学式: C₉H₁₂F₃NO₃
• 分子量: 239.194
• InChiKey: NJAZHBNXTSUHKE-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  methyl (2S)-2-[(2,2,2-trifluoroacetyl)amino]hex-5-enoate 在 sodium periodate 、 四氧化锇 作用下， 以 四氢呋喃 为溶剂， 生成 methyl (2S)-5-oxo-2-[(2,2,2-trifluoroacetyl)amino]pentanoate
  参考文献：
  名称：

  A novel strategy toward [6,5]-bicyclic β-turn dipeptide

  摘要：

  A novel strategy toward the syntheses of [6,5]-bicyclic beta-turn dipeptides has been developed starting from delta,epsilon-unsaturated amino acids. This is the first example showing that this scaffold can be synthesized front a terminal alkene using a trifluoroacetyl protected amino acid. Both enantiomers of the delta,epsilon-unsaturated amino acid were synthesized by a modified method using Ni(II)-complexes. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01338-2
• 作为产物：
  描述：

  (S)-2-氨基己-5-烯酸 生成 methyl (2S)-2-[(2,2,2-trifluoroacetyl)amino]hex-5-enoate
  参考文献：
  名称：

  A novel strategy toward [6,5]-bicyclic β-turn dipeptide

  摘要：

  A novel strategy toward the syntheses of [6,5]-bicyclic beta-turn dipeptides has been developed starting from delta,epsilon-unsaturated amino acids. This is the first example showing that this scaffold can be synthesized front a terminal alkene using a trifluoroacetyl protected amino acid. Both enantiomers of the delta,epsilon-unsaturated amino acid were synthesized by a modified method using Ni(II)-complexes. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01338-2

文献信息

• A novel strategy toward [6,5]-bicyclic β-turn dipeptide
  作者：Xuyuan Gu、Xuejun Tang、Scott Cowell、Jinfa Ying、Victor J. Hruby

  DOI：10.1016/s0040-4039(02)01338-2

  日期：2002.9

  A novel strategy toward the syntheses of [6,5]-bicyclic beta-turn dipeptides has been developed starting from delta,epsilon-unsaturated amino acids. This is the first example showing that this scaffold can be synthesized front a terminal alkene using a trifluoroacetyl protected amino acid. Both enantiomers of the delta,epsilon-unsaturated amino acid were synthesized by a modified method using Ni(II)-complexes. (C) 2002 Elsevier Science Ltd. All rights reserved.