4-[1-(5-Chloro-2-phenylmethoxyphenyl)ethoxy]-3-ethoxybenzaldehyde | 670275-17-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-[1-(5-Chloro-2-phenylmethoxyphenyl)ethoxy]-3-ethoxybenzaldehyde
• CAS: 670275-17-9
• 化学式: C₂₄H₂₃ClO₄
• 分子量: 410.897
• InChiKey: KDJXROZLQOBDPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-[1-(5-Chloro-2-phenylmethoxyphenyl)ethoxy]-3-ethoxybenzaldehyde 在 sodium tetrahydroborate 、 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 5-[[4-[1-(5-Chloro-2-phenylmethoxyphenyl)ethoxy]-3-ethoxyphenyl]methoxy]-2-nitrobenzaldehyde
  参考文献：
  名称：

  Synthesis of Ether Oligomers

  摘要：

  Hydroxyaromatic aldehydes and ketones were used as building blocks to prepare ether oligomers. An iterative two-step protocol involving Mitsunobu coupling and carbonyl reduction provided a protecting-group-free route with high yields. Activity screening of an 84-member library against proteases led to the discovery of micromolar inhibitors for trypsin, chymotrypsin, and subtilisin.

  DOI：

  10.1021/ol036300d
• 作为产物：
  描述：

  1-[5-氯-2-(苯基甲氧基)苯基]乙酮 在 sodium tetrahydroborate 、 偶氮二甲酸二异丙酯 、 三苯基膦 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 4-[1-(5-Chloro-2-phenylmethoxyphenyl)ethoxy]-3-ethoxybenzaldehyde
  参考文献：
  名称：

  Synthesis of Ether Oligomers

  摘要：

  Hydroxyaromatic aldehydes and ketones were used as building blocks to prepare ether oligomers. An iterative two-step protocol involving Mitsunobu coupling and carbonyl reduction provided a protecting-group-free route with high yields. Activity screening of an 84-member library against proteases led to the discovery of micromolar inhibitors for trypsin, chymotrypsin, and subtilisin.

  DOI：

  10.1021/ol036300d

文献信息

• Synthesis of Ether Oligomers
  作者：Olivier Renaudet、Jean-Louis Reymond

  DOI：10.1021/ol036300d

  日期：2004.2.1

  Hydroxyaromatic aldehydes and ketones were used as building blocks to prepare ether oligomers. An iterative two-step protocol involving Mitsunobu coupling and carbonyl reduction provided a protecting-group-free route with high yields. Activity screening of an 84-member library against proteases led to the discovery of micromolar inhibitors for trypsin, chymotrypsin, and subtilisin.