2-[4-(2-chloro-pyridin-4-ylethynyl)-2-methyl-imidazol-1-yl]-6-methyl-4-trifluoromethyl-pyridine | 802906-74-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[4-(2-chloro-pyridin-4-ylethynyl)-2-methyl-imidazol-1-yl]-6-methyl-4-trifluoromethyl-pyridine
• 英文别名: 2-[4-(2-chloro-pyridin-4-ylethynyl)-2-methyl-imidazolyl-1-yl]-6-methyl-4-trifluoromethyl-pyridine；2-[4-[2-(2-Chloropyridin-4-yl)ethynyl]-2-methylimidazol-1-yl]-6-methyl-4-(trifluoromethyl)pyridine
• CAS: 802906-74-7
• 化学式: C₁₈H₁₂ClF₃N₄
• 分子量: 376.768
• InChiKey: UUDYTQQGFFKWSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  43.6
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Imidazole derivatives
  申请人：——

  公开号：US20040248888A1

  公开（公告）日：2004-12-09

  The present invention relates to imidazole derivatives of formula I 1 wherein R 1 , R 2 , R 3 and R 4 are described hereinbelow. These compounds can be used in the treatment or prevention of mGluR5 receptor mediated disorders. These compounds are useful, inter alia, in the treatment or prevention of acute and/or chronic neurological disorders such as psychosis, epilepsy, schizophrenia, Alzheimer' disease, cognititve disorders and memory deficits, as well as chronic and acute pain.

  本发明涉及以下式I1的咪唑衍生物，其中R1、R2、R3和R4如下所述。这些化合物可用于治疗或预防mGluR5受体介导的疾病。这些化合物可用于治疗或预防急性和/或慢性神经系统疾病，如精神病、癫痫、精神分裂症、阿尔茨海默病、认知障碍和记忆缺陷，以及慢性和急性疼痛。
• IMIDAZOLE DERIVATIVES
  申请人：Buettelmann Bernd

  公开号：US20080103306A1

  公开（公告）日：2008-05-01

  The present invention relates to process for the preparation of an imidazole derivative of formula I, wherein R 1 , R 2 , R 3 and R 4 are described hereinabove. These compounds can be used in the treatment or prevention of mGluR5 receptor mediated disorders. These compounds are useful, inter alia, in the treatment or prevention of acute and/or chronic neurological disorders such as psychosis, epilepsy, schizophrenia, Alzheimer' disease, cognitive disorders and memory deficits, as well as chronic and acute pain.

  本发明涉及制备式I的咪唑衍生物的方法，其中R1、R2、R3和R4如上所述。这些化合物可用于治疗或预防mGluR5受体介导的疾病。这些化合物在治疗或预防急性和/或慢性神经系统疾病，如精神病、癫痫、精神分裂症、阿尔茨海默病、认知障碍和记忆障碍以及慢性和急性疼痛方面是有用的。
• IMIDAZOLE DERIVATIVES AS GLUTMATE RECEPTOR ANTAGONISTS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1636206B1

  公开（公告）日：2007-10-31
• US7332510B2
  申请人：——

  公开号：US7332510B2

  公开（公告）日：2008-02-19
• US7531529B2
  申请人：——

  公开号：US7531529B2

  公开（公告）日：2009-05-12