Copper;2-amino-3-(4-hydroxyphenyl)propanoate | 12320-32-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Copper;2-amino-3-(4-hydroxyphenyl)propanoate
• CAS: 12320-32-0；14407-55-7；15392-80-0；15417-71-7；18750-45-3；25319-18-0；67336-56-5
• 化学式: C₁₈H₂₀CuN₂O₆
• 分子量: 423.913
• InChiKey: VEGMEJOSPCRZGL-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -1.98
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  173
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  四苯基卟啉 、 Copper;2-amino-3-(4-hydroxyphenyl)propanoate 以 二甲基亚砜 为溶剂， 生成 (tetraphenylporphyrin)copper(II)
  参考文献：
  名称：

  摘要：

  The reactions of tetraphenylporphine (H2TPP) with copper(II) chelates in DMSO were studied. alpha-Amino acids (glycine, alpha-alanine, valine, leucine, tyrosine, and glutamine) were used as chelating ligands. The study of the reaction kinetics showed that Cu(II) chelates with alanine and the other amino acids are less reactive in these reactions than acetylacetonates, alpha-nitroso-beta-naphtholates, and hydroxyquinolates. The exception is a Cu(II) complex with tyrosine. The relationship between the structure of the above chelates and the rate of their reactions with porphyrin was determined.

  DOI：

  10.1023/a:1021102814028

文献信息

• Process to obtain new mixed copper aminoacidate complexes from phenanthrolines and their alkyl derivatives to be used as anticancerigenic agents
  申请人：UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO

  公开号：EP0434445A2

  公开（公告）日：1991-06-26

  This invention refers to a process to obtain new mixed copper aminoacidates from phenanthrolines and their alkyl derivates of an aromatic type to be used as anticancerigenic, agents preferably with a therapeutic use for the treatment of liquid and solid cancerigenic tumours such as leukemia. The complexes obtained are of the [Cu (N-N) (N-O)]⁺⁻ NO₃ type in which the N-N ligand corresponds to 4, 7-dimethyl-1, 10 phenanthroline and the N-O ligand preferably correponds to one of the aminoacidates such as tyrosine-alaninate, treoninate, triptophanate, valinate, isoleucinate, cisteinate, diglycinate, phenylalaninate, glycinate, hystidinate, serinate, tyrosinate, aspartate, alaninate and phenylalaninate. The process is characterized because it includes the following steps: making an aqueous solution based on an aliphatic alcohol and 4, 7-dimethyl-1, 10 phenanthroline react with a copper complex preferably CuNO₃5H₂O at room temperature, and immediately after making the obtained product react in an aqueous aminoacidate solution adjusting a slightly alkaline pH.

  本发明涉及一种从菲罗啉及其芳香族烷基衍生物中获得新的混合氨基酸铜的工艺，该工艺可用作抗癌剂，优选用于治疗液态和固态致癌肿瘤，如白血病。所获得的配合物为[Cu (N-N) (N-O)]⁺- NO₃型，其中 N-N 配体对应于 4，7-二甲基-1，10-菲罗啉，N-O 配体最好对应于氨基酸盐之一，如酪氨酸丙氨酸盐、曲安酸盐、三色氨酸盐、氨酸、三色氨酸、缬氨酸、异亮氨酸、肌氨酸、二甘氨酸、苯丙氨酸、甘氨酸、胱氨酸、丝氨酸、酪氨酸、天门冬氨酸、丙氨酸和苯丙氨酸。该工艺的特点是包括以下步骤：在室温下，使基于脂肪醇和 4，7-二甲基-1，10-菲罗啉的水溶液与铜络合物（最好是 CuNO₃5H₂O）反应，然后立即使得到的产物在调节 pH 值为微碱性的氨基酸水溶液中反应。
• Composition for promoting healthy bone structure
  申请人：——

  公开号：US20030059481A1

  公开（公告）日：2003-03-27

  A dietary supplement for benefitting human bone health includes a calcium source, a source of vitamin D activity, and an osteoblast stimulant. A preferred calcium source is microcrystalline hydroxyapatite, which also contains protein (mostly collagen), phosphorus, fat, and other minerals. A preferred source of vitamin D activity is cholecalciferol, and a preferred osteoblast stimulant is ipriflavone. In addition to these basic ingredients, the composition can further include various other minerals known to occur in bone, vitamin C, and glucosamine sulfate, all of which exert beneficial effects on growth and maintenance of healthy bone. A method for benefitting human bone health involves administering a daily regimen of the dietary supplement.

  一种有益于人体骨骼健康的膳食补充剂包括一种钙源、一种维生素 D 活性源和一种成骨细胞刺激剂。首选的钙源是微晶羟磷灰石，它还含有蛋白质（主要是胶原蛋白）、磷、脂肪和其他矿物质。维生素 D 活性的首选来源是胆钙化醇，刺激成骨细胞的首选成分是异丙基三黄酮。除了这些基本成分外，组合物还可进一步包括已知存在于骨骼中的其他各种矿物质、维生素 C 和硫酸氨基葡萄糖，所有这些成分都对健康骨骼的生长和维持产生有益的影响。有益于人体骨骼健康的方法包括每天服用这种膳食补充剂。
• DIETARY SUPPLEMENTS COMPRISING VITAMINS AND MINERALS
  申请人：LifeScience Corporation

  公开号：EP0514451B1

  公开（公告）日：1997-01-15
• COMPOSITIONS AND METHODS FOR THE PRESERVATION OF WOOD
  申请人：Abou-Nemeh Ibrahim

  公开号：US20070227399A1

  公开（公告）日：2007-10-04

  The present invention provides compositions and methods for preserving wood. The compositions generally include at least one metal chelate or metal salt of a hydroxy analog of methionine. The method generally involves contacting wood or a wood material with a wood preservation composition of the invention. The invention also includes wood or wood products treated with a wood preservation composition of the invention.
• Methods for determining the metal bioavailability of metal sources
  申请人：Richards James David

  公开号：US20080090297A1

  公开（公告）日：2008-04-17

  The invention provides methods for determining the relative metal bioavailability of a metal source in an animal or group of animals. The method may be utilized to compare the relative metal bioavailability between different metal sources and it may be used to determine the relative nutritional status of a metal in an animal or group of animals.