Benzoylalanylchlorid | 880257-32-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Benzoylalanylchlorid
• 英文别名: (2S)-2-benzamidopropanoyl chloride
• CAS: 880257-32-9
• 化学式: C₁₀H₁₀ClNO₂
• 分子量: 211.648
• InChiKey: FXZGELBLAKATLN-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Benzoylalanylchlorid 在 三乙胺 作用下， 以 四氢呋喃 、 1,2-二氯乙烷 为溶剂， 反应 12.0h， 生成 methyl benzoyl-L-alanylglycinate
  参考文献：
  名称：

  一类稳定酰胺在可见光照射下通过自芳构化作为酰基转移试剂

  摘要：

  合成了一种新型稳定的酰胺，在光照射下可以与酰氯等各种亲核试剂发生反应。这种可控的开启反应性取决于合理设计的光激活掩蔽酰基供体试剂。

  DOI：

  10.1002/chem.202401619
• 作为产物：
  描述：

  N-苯甲酰-L-丙氨酸 在 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 为溶剂， 以100%的产率得到Benzoylalanylchlorid
  参考文献：
  名称：

  一类稳定酰胺在可见光照射下通过自芳构化作为酰基转移试剂

  摘要：

  合成了一种新型稳定的酰胺，在光照射下可以与酰氯等各种亲核试剂发生反应。这种可控的开启反应性取决于合理设计的光激活掩蔽酰基供体试剂。

  DOI：

  10.1002/chem.202401619

文献信息

• 4-Pyrimidinamine derivatives, pharmaceutical compositions and related methods
  申请人：——

  公开号：US20030008883A1

  公开（公告）日：2003-01-09

  This invention provides novel neuroprotective 4-pyrimidineamine derivatives and neuroprotective pharmaceutical compositions comprising 4-pyrimidinamines. This invention also provides methods of using these compositions to prevent ischemic cell death, particularly neuronal cell death, and reduce the likelihood of neuronal cell death in a subject due to a traumatic event. Finally, this invention provides an apparatus for administering to a subject the instant pharmaceutical compositions.

  该发明提供了新型的神经保护性4-嘧啶胺衍生物和包含4-嘧啶胺的神经保护性药物组合物。该发明还提供了使用这些组合物预防缺血性细胞死亡，特别是神经细胞死亡，并减少由于外伤事件导致受试者神经细胞死亡的可能性的方法。最后，该发明提供了一种用于向受试者施用上述药物组合物的装置。
• 4-pyrimidinamine derivatives, pharmaceutical compositions and related methods
  申请人：——

  公开号：US20030212079A1

  公开（公告）日：2003-11-13

  This invention provides novel neuroprotective 4-pyrimidineamine derivatives and neuroprotective pharmaceutical compositions comprising 4-pyrimidinamines. This invention also provides methods of using these compositions to prevent ischemic cell death, particularly neuronal cell death, and reduce the likelihood of neuronal cell death in a subject due to a traumatic event. Finally, this invention provides an apparatus for administering to a subject the instant pharmaceutical compositions.

  本发明提供了新型神经保护性的4-嘧啶胺衍生物以及包含4-嘧啶胺的神经保护性药物组合物。本发明还提供使用这些组合物预防缺血性细胞死亡，特别是神经元细胞死亡，并减少由于创伤事件导致的受试者神经元细胞死亡的可能性的方法。最后，本发明提供了一种用于向受试者输送即时药物组合物的装置。
• Inhibitors of HCV NS5A: From Iminothiazolidinones to Symmetrical Stilbenes
  作者：Jeffrey L. Romine、Denis R. St. Laurent、John E. Leet、Scott W. Martin、Michael H. Serrano-Wu、Fukang Yang、Min Gao、Donald R O’Boyle、Julie A. Lemm、Jin-Hua Sun、Peter T. Nower、Xiaohua (Stella) Huang、Milind S. Deshpande、Nicholas A. Meanwell、Lawrence B. Snyder

  DOI：10.1021/ml1002647

  日期：2011.3.10

  The iminothiazolidinone BMS-858 (2) was identified as a specific inhibitor of HCV replication in a genotype 1b replicon assay via a high-throughput screening campaign. A more potent analogue, BMS-824 (18), was used in resistance mapping studies, which revealed that inhibitory activity was related to disrupting the function of the HCV nonstructural protein 5A. Despite the development of coherent and interpretable SAIL, it was subsequently discovered that in DMSO 18 underwent an oxidation and structural rearrangement to afford the thiohydantoin 47, a compound with reduced HCV inhibitory activity. However, HPLC bioassay fractionation studies performed after incubation of 18 in assay media led to the identification of fractions containing a dimeric species 48 that exhibited potent antiviral activity. Excision of the key elements hypothesized to be responsible for antiviral activity based on SAR observations reduced 48 to a simplified, symmetrical, pharmacophore realized most effectively with the stilbene 55, a compound that demonstrated potent inhibition of HCV in a genotype 1b replicon with an EC50 = 86 pM.
• 4-PYRIMIDINAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND RELATED METHODS
  申请人：Ortho-McNeil Pharmaceutical, Inc.

  公开号：EP1313713A2

  公开（公告）日：2003-05-28
• [EN] 4-PYRIMIDINAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND RELATED METHODS<br/>[FR] DERIVES 4-PYRIMIDINAMINES, COMPOSITIONS PHARMACEUTIQUES ET PROCEDES ASSOCIES
  申请人：ORTHO MCNEIL PHARM INC

  公开号：WO2002012198A2

  公开（公告）日：2002-02-14

  This invention provides novel neuroprotective 4-pyrimidineamine derivatives and neuroprotective pharmaceutical compositions comprising 4-pyrimidinamines. This invention also provides methods of using these compositions to prevent ischemic cell death, particularly neuronal cell death, and reduce the likelihood of neuronal cell death in a subject due to a traumatic event. Finally, this invention provides an apparatus for administering to a subject the instant pharmaceutical compositions.