H-Glu(O-t-Bu)-Gln(Trt)-Pheol | 1053260-12-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-Glu(O-t-Bu)-Gln(Trt)-Pheol
• 英文别名: H-Glu(OtBu)(OtBu)-Gln(Trt)(Trt)-Phe-ol；tert-butyl (4S)-4-amino-5-[[(2S)-1-[[(2S)-1-hydroxy-3-phenylpropan-2-yl]amino]-1,5-dioxo-5-(tritylamino)pentan-2-yl]amino]-5-oxopentanoate
• CAS: 1053260-12-0
• 化学式: C₄₂H₅₀N₄O₆
• 分子量: 706.882
• InChiKey: PBDVBCUEHIYYBZ-KVBYWJEESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  52
• 可旋转键数：
  19
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  160
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Z-Leu-Aib-Pro-Val-Aib-Aib-OH 、 H-Glu(O-t-Bu)-Gln(Trt)-Pheol 在 N-羟基-7-氮杂苯并三氮唑 、 2-chloro-1,3-dimethylimidazolidium hexafluorophosphate 作用下， 以 二氯甲烷 为溶剂， 反应 60.0h， 生成 Z-Leu-Aib-Pro-Val-Aib-Aib-Glu(O-t-Bu)-Gln(Trt)-Pheol
  参考文献：
  名称：

  Efficient synthesis of alamethicin f-30 using a chloro imidazolidium coupling reagent, CIP

  摘要：

  Alamethicin F-30 has been synthesized in solution using a CIP-additive as a coupling agent and TFA as a final deprotecting reagent. All couplings including those between sterically hindered alpha,alpha-dimethyl amino acid were successfully achieved by a 60 min reaction.

  DOI：

  10.1016/0040-4039(95)02023-i
• 作为产物：
  描述：

  Fmoc-Glu(O-t-Bu)-Gln(Trt)-Pheol 在 二乙胺 作用下， 生成 H-Glu(O-t-Bu)-Gln(Trt)-Pheol
  参考文献：
  名称：

  Efficient synthesis of alamethicin f-30 using a chloro imidazolidium coupling reagent, CIP

  摘要：

  Alamethicin F-30 has been synthesized in solution using a CIP-additive as a coupling agent and TFA as a final deprotecting reagent. All couplings including those between sterically hindered alpha,alpha-dimethyl amino acid were successfully achieved by a 60 min reaction.

  DOI：

  10.1016/0040-4039(95)02023-i

文献信息

• Efficient synthesis of alamethicin f-30 using a chloro imidazolidium coupling reagent, CIP
  作者：Kenichi Akaji、Yasunori Tamai、Yoshiaki Kiso

  DOI：10.1016/0040-4039(95)02023-i

  日期：1995.12

  Alamethicin F-30 has been synthesized in solution using a CIP-additive as a coupling agent and TFA as a final deprotecting reagent. All couplings including those between sterically hindered alpha,alpha-dimethyl amino acid were successfully achieved by a 60 min reaction.