Dibenzyl 5-[[3-[[3,5-bis(phenylmethoxycarbonyl)phenyl]methoxycarbonyl]-5-(chloromethyl)benzoyl]oxymethyl]benzene-1,3-dicarboxylate | 244242-25-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Dibenzyl 5-[[3-[[3,5-bis(phenylmethoxycarbonyl)phenyl]methoxycarbonyl]-5-(chloromethyl)benzoyl]oxymethyl]benzene-1,3-dicarboxylate
• CAS: 244242-25-9
• 化学式: C₅₅H₄₃ClO₁₂
• 分子量: 931.392
• InChiKey: LQTIJZCDCHIAMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.4
• 重原子数：
  68
• 可旋转键数：
  25
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  158
• 氢给体数：
  0
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  、 Dibenzyl 5-[[3-[[3,5-bis(phenylmethoxycarbonyl)phenyl]methoxycarbonyl]-5-(chloromethyl)benzoyl]oxymethyl]benzene-1,3-dicarboxylate 在 N,N-二异丙基乙胺 、 potassium bromide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以89%的产率得到Bis[[3,5-bis[[3,5-bis(phenylmethoxycarbonyl)phenyl]methoxycarbonyl]phenyl]methyl] 5-(hydroxymethyl)benzene-1,3-dicarboxylate
  参考文献：
  名称：

  A Rapid, Orthogonal Synthesis of Poly(benzyl ester) Dendrimers via an “Activated” Monomer Approach

  摘要：

  Herein we introduce the concept of an "activated" monomer approach to the synthesis of convergent dendrimers. In this method a set of chemically orthogonal monomers, one of which is an "activated" analogue of the other, is used to rapidly synthesize large, perfect dendrimers with one additional generation being added in each reaction. This method is exemplified by the efficient preparation of a new family of poly(benzyl ester) dendrimers described below.

  DOI：

  10.1021/ol9907724
• 作为产物：
  描述：

  5-(羟甲基)间苯二甲酸 在 氯化亚砜 、 potassium carbonate 、 三乙胺 、 N,N'-二环己基碳二亚胺 、 DPTS 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 Dibenzyl 5-[[3-[[3,5-bis(phenylmethoxycarbonyl)phenyl]methoxycarbonyl]-5-(chloromethyl)benzoyl]oxymethyl]benzene-1,3-dicarboxylate
  参考文献：
  名称：

  A Rapid, Orthogonal Synthesis of Poly(benzyl ester) Dendrimers via an “Activated” Monomer Approach

  摘要：

  Herein we introduce the concept of an "activated" monomer approach to the synthesis of convergent dendrimers. In this method a set of chemically orthogonal monomers, one of which is an "activated" analogue of the other, is used to rapidly synthesize large, perfect dendrimers with one additional generation being added in each reaction. This method is exemplified by the efficient preparation of a new family of poly(benzyl ester) dendrimers described below.

  DOI：

  10.1021/ol9907724

文献信息

• A Rapid, Orthogonal Synthesis of Poly(benzyl ester) Dendrimers via an “Activated” Monomer Approach
  作者：Adam W. Freeman、Jean M. J. Fréchet

  DOI：10.1021/ol9907724

  日期：1999.8.1

  Herein we introduce the concept of an "activated" monomer approach to the synthesis of convergent dendrimers. In this method a set of chemically orthogonal monomers, one of which is an "activated" analogue of the other, is used to rapidly synthesize large, perfect dendrimers with one additional generation being added in each reaction. This method is exemplified by the efficient preparation of a new family of poly(benzyl ester) dendrimers described below.