{tert-Butoxycarbonyl-[2-(methoxy-methyl-carbamoyl)-ethyl]-amino}-acetic acid ethyl ester | 170123-28-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: {tert-Butoxycarbonyl-[2-(methoxy-methyl-carbamoyl)-ethyl]-amino}-acetic acid ethyl ester
• 英文别名: Ethyl 2-[[3-[methoxy(methyl)amino]-3-oxopropyl]-[(2-methylpropan-2-yl)oxycarbonyl]amino]acetate
• CAS: 170123-28-1
• 化学式: C₁₄H₂₆N₂O₆
• 分子量: 318.37
• InChiKey: FCHMZFXLAOIKIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  22
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  85.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  {tert-Butoxycarbonyl-[2-(methoxy-methyl-carbamoyl)-ethyl]-amino}-acetic acid ethyl ester 在 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以73%的产率得到n-boc-3-氧代吡咯烷-2-羧酸乙酯
  参考文献：
  名称：

  Chemoselective Dieckmann-like condensations using N-methoxy-N-methylamides

  摘要：

  The use of N-methoxy-N-methylamide as a chemoselective group in Dieckmann-like condensation is described. The chemoselectivity in these cyclizations is dependent on the counterion of the base employed.

  DOI：

  10.1016/0040-4039(95)01251-c
• 作为产物：
  描述：

  二碳酸二叔丁酯 、 [2-(Methoxy-methyl-carbamoyl)-ethylamino]-acetic acid ethyl ester 生成 {tert-Butoxycarbonyl-[2-(methoxy-methyl-carbamoyl)-ethyl]-amino}-acetic acid ethyl ester
  参考文献：
  名称：

  Chemoselective Dieckmann-like condensations using N-methoxy-N-methylamides

  摘要：

  The use of N-methoxy-N-methylamide as a chemoselective group in Dieckmann-like condensation is described. The chemoselectivity in these cyclizations is dependent on the counterion of the base employed.

  DOI：

  10.1016/0040-4039(95)01251-c

文献信息

• New strategies towards proline derivatives as conformationally constrained arginine analogues
  作者：Nadia Pellegrini、Martine Schmitt、Sébastien Guery、Jean-Jacques Bourguignon

  DOI：10.1016/s0040-4039(02)00424-0

  日期：2002.4

  The cyano derivatives of 3-functionalized dehydroprolines led to arginine semi-constrained analogues. (C) 2002 Elsevier Science Ltd. All rights reserved.
• Chemoselective Dieckmann-like condensations using N-methoxy-N-methylamides
  作者：Mukund P. Sibi、James W. Christensen、Sung-Gyu Kim、MariJean Eggen、Chad Stessman、Larry Oien

  DOI：10.1016/0040-4039(95)01251-c

  日期：1995.8

  The use of N-methoxy-N-methylamide as a chemoselective group in Dieckmann-like condensation is described. The chemoselectivity in these cyclizations is dependent on the counterion of the base employed.