Pfmrk Inhibitor, WR 216174

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: Pfmrk Inhibitor, WR 216174
• 英文别名: (3Z)-5-bromo-3-[2-(4-fluorophenyl)-2-oxoethylidene]-1H-indol-2-one
• 化学式: C₁₆H₉BrFNO₂
• 分子量: 346.15
• InChiKey: VVBIXEJMWRHSLL-JYRVWZFOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS TO THE PANCREATIC ENDOCRINE LINEAGE
  申请人：Janssen Biotech, Inc.

  公开号：EP2346988B1

  公开（公告）日：2017-05-31
• Differentiation of Human Embryonic Stem Cells
  申请人：Rezania Alireza

  公开号：US20100112693A1

  公开（公告）日：2010-05-06

  The present invention provides a method for increasing the expression of MAFA in cells expressing markers characteristic of the pancreatic endocrine lineage comprising the steps of culturing the cells expressing markers characteristic of the pancreatic endocrine lineage in medium comprising a sufficient amount of a cyclin-dependant kinase inhibitor to cause an increase in expression of MAFA.
• Differentiation of Human Pluripotent Stem Cells
  申请人：Janssen Biotech, Inc.

  公开号：US20160160182A1

  公开（公告）日：2016-06-09

  The present invention provides a method for increasing the expression of MAFA in cells expressing markers characteristic of the pancreatic endocrine lineage comprising the steps of culturing the cells expressing markers characteristic of the pancreatic endocrine lineage in medium comprising a sufficient amount of a cyclin-dependent kinase inhibitor to cause an increase in expression of MAFA.
• US9234178B2
  申请人：——

  公开号：US9234178B2

  公开（公告）日：2016-01-12
• US9752126B2
  申请人：——

  公开号：US9752126B2

  公开（公告）日：2017-09-05